An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis  

作　　者：Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He 

机构地区：[1]National Key Laboratory of Plant Molecular Genetics,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology&Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China [2]University of the Chinese Academy of Sciences,Beijing 100049,China [3]School of Life Science and Technology,Shanghai Tech University,Shanghai 201210,China [4]State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing),Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [5]Shanghai Center for Plant Stress Biology,Chinese Academy of Sciences,Shanghai 201602,China [6]Institute of Biochemistry and Biology,University of Potsdam,Potsdam,Germany [7]Department of Molecular,Cellular,and Developmental Biology,University of Michigan,Ann Arbor,MI 48109,USA [8]CAS Center for Excellence in Molecular Plant Sciences,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Cell Research》2019年第5期379-390,共12页细胞研究（英文版）

基　　金：the National Natural Science Foundation of China(91640114 and 31330061 to Z.H,31788103 and 91540203 to X.C.,31600207 to J.L.and 31770323 to X.D);Chinese Academy of Sciences(XDB27040201 to Z.H,QYZDYSSW-SMC022 to X.C.);the National Key Laboratory of Plant Molecular Genetics and the State Key Laboratory of Plant Genomics,the China Postdoctoral Science Foundation(2016M590386 to J.L);the Youth Innovation Promotion Association of CAS(2018131 to X.D.).

摘　　要：Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation.

关 键 词：AN H3K27me3 demethylase-HSFA2 GLOBAL WARMING 

分 类 号：Q[生物学]