红细胞悬浊液与洗涤红细胞对早产贫血患儿血液流变学参数的影响及临床应用价值  

Effect of erythrocyte suspension and washed erythrocyte on hemorheological parameters of premature anemia children and its clinical application value

作　　者：蔡世川[1] 杨勇 李一鹏[3] CAI Shi-chuan;YANG Yong;LI Yi-peng(Department of Laboratory,Dalian Children’s Hospital,Dalian 116000,China)

机构地区：[1]大连市儿童医院检验科,116000 [2]大连市妇幼保健院检验科,116000 [3]大连市中医医院检验科,116000

出　　处：《中国现代药物应用》2019年第10期24-25,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨输注红细胞悬浊液与洗涤红细胞对早产贫血患儿血液流变学参数的影响及临床应用价值。方法 80例早产贫血患儿,根据输血方式不同分为红细胞悬浊液组与洗涤红细胞组,各40例。红细胞悬浊液组输注红细胞悬浊液,洗涤红细胞组输注洗涤红细胞。比较两组早产贫血患儿输血后血液流变学参数(全血高切粘度、全血低切粘度、血浆粘度)和S-亚硝基硫醇(RSNO)、超氧化物歧化酶(SOD)、丙二醛(MDA)。结果输血后,洗涤红细胞组全血高切粘度(4.12±0.63)mPa·s、全血低切粘度(7.45±1.34)mPa·s、血浆粘度(1.14±0.28)mPa·s优于红细胞悬浊液组的(5.03±0.85)mPa·s、(10.47±1.81)mPa·s、(1.61±0.51)mPa·s,差异具有统计学意义(P<0.05);输血后,洗涤红细胞组RSNO、SOD、MDA优于红细胞悬浊液组,差异具有统计学意义(P<0.05)。结论红细胞悬液与洗涤红细胞相比,洗涤红细胞对早产贫血患儿的机体影响较小,值得在临床推广。Objective To discuss the effect of erythrocyte suspension and washed erythrocyte on hemorheological parameters of premature anemia children and its clinical application value. Methods A total of 80 premature anemia children were divided by different blood transfusion modes into erythrocyte suspension group and washed erythrocyte group, with 40 cases in each group. Erythrocyte suspension group was transfused with erythrocyte suspension and washed erythrocyte group was transfused with washed erythrocyte. Comparison were made on hemorheological parameters (whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity) and S-nitrosothiol (RSNO), superoxide dismutase (SOD), malondialdehyde (MDA) after transfusion between the two groups. Results After transfusion, washed erythrocyte group had better whole blood high shear viscosity as (4.12±0.63) mPa·s, whole blood low shear viscosity as (7.45±1.34) mPa·s and plasma viscosity as (1.14±0.28) mPa·s than (5.03±0.85) mPa·s,(10.47±1.81) mPa·s and (1.61±0.51) mPa·s in washed erythrocyte, and their difference was statistically significant (P<0.05). After transfusion, washed erythrocyte group had better RSNO, SOD and MDA than washed erythrocyte, and the difference was statistically significant (P<0.05). Conclusion Compared with erythrocyte suspension, washed erythrocyte has less influence on the body of preterm anemia children, and it is worthy of clinical promotion.

关 键 词：红细胞悬浊液 洗涤红细胞 早产 贫血 

分 类 号：R722.6[医药卫生—儿科]