辐射影响细胞色素P450的研究进展  

Research progress on the effect of radiation on cytochrome P450

作　　者：辛元尧 年永琼 李向阳[2,3] XIN Yuanyao;NIAN Yongqiong;LI Xiangyang(College of Ecological and Environment Engineering,Qinghai University,Xining 810016,China;Medical College,Qinghai University,Xining 810001,China;State Key Laboratory of Plateau Ecology and Agriculture,Qinghai University,Xining 810016,China)

机构地区：[1]青海大学生态环境工程学院,青海西宁810016 [2]青海大学医学院,青海西宁810001 [3]青海大学三江源生态与高原农牧业国家重点实验室,青海西宁810016

出　　处：《药学研究》2019年第5期280-285,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金项目(No.81460568);教育部新世纪优秀人才支撑计划资助项目(No.NCET-10-0917);青海省自然科学基金资助项目(No.2019-ZJ-918)

摘　　要：随着科学的进步,核能和核技术已经广泛应用于医疗、能源、军事、食品加工等国防和国民生活的方方面面。可能受到辐射损伤的人群主要有接受放疗的癌症患者、从事与放射相关的工作人员和生活在高原地区的人们等。辐射条件下机体产生一系列生理性变化,部分为病理性变化,从而影响药物在体内的吸收、分布、代谢和排泄,导致药物代谢动力学特征发生改变。关注这些人群的个体化用药,逐渐成为医学和药学科研人员研究的重点。本文综述了环境及临床治疗的电离及非电离辐射对细胞色素P450的影响。With the progress of science,nuclear energy and nuclear technology have been widely used in medical,energy,military,food processing and other aspects of national defense and national life.Potential radiation injuries include cancer patients receiving radiation therapy,radiation-related workers and people living in Plateau areas.Under radiation,a series of physiological changes,some of which are pathological changes,affect the absorption,distribution,metabolism and excretion of drugs in the body,resulting in changes in pharmacokinetic characteristics.Focusing on the individualized medication of these populations has gradually become the focus of research in medical and pharmaceutical research.The effects of ionizing and non ionizing radiation on cytochrome P450 were reviewed in this paper.

关 键 词：辐射 细胞色素P450 药物代谢 研究进展 

分 类 号：R146[医药卫生—公共卫生与预防医学]