IL-8基因rs4073位点与新疆维吾尔族男性高尿酸血症患者关联性研究  

Association study on IL-8 gene rs4073 locus and hyperuricemia in males in Xinjiang Uygur

作　　者：张蓓[1] 陆影[2] 玛伊娜.卡哈尔 迪丽达尔.库德热提 田戈[3] 宋睿睿 张晓波 杨珊珊[5] 孙玉萍[1] ZHANG Bei;LU Ying;MAYINA·Kahaer;DILIDAER·Kudereti;TIAN Ge;SONG Ruirui;ZHANG Xiaobo;YANG Shanshan;SUN Yuping(School of Basic Medicine,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;First Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Affiliated Chinese Medicine Hospital/Xinjiang Key Laboratory of Respiratory Diseases,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Graduate School,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;Fifth Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学基础医学院,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院,新疆乌鲁木齐830011 [3]新疆医科大学附属中医医院/新疆呼吸病重点实验室,新疆乌鲁木齐830011 [4]新疆医科大学研究生学院,新疆乌鲁木齐830011 [5]新疆医科大学第五附属医院检验科,新疆乌鲁木齐830011

出　　处：《国际检验医学杂志》2019年第10期1161-1164,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81760169;81560153);新疆维吾尔自治区自然科学基金项目(2017D01C234;2019D01C218);上海市第六人民医院/上海市糖尿病重点实验室开放课题(SHKLD-KF-1502)

摘　　要：目的了解新疆维吾尔族白细胞介素-8(IL-8)基因多态性与高尿酸血症的关联。方法选择2012年2月至2013年9月新疆医科大学第一附属医院、喀什第一人民医院、吐鲁番医院、托里县人民医院体检中心进行体检的、在少数民族居住区的、20～60岁维吾尔族男性1 168例作为研究对象,其中对照组594例,高尿酸血症组574例。进行一般体格检查、尿酸及肾功能相关指标检测,并使用Taqman探针法检测白介素相关基因——IL-8的基因多态性。高尿酸血症组为空腹血清尿酸超过417μmol/L者。结果高尿酸血症组患者IL-8基因rs4073位点基因型分布频率、等位基因频率分布与对照组比较,差异均有统计学意义(P<0.05);IL-8基因rs4073位点变异型基因罹患高尿酸血症的风险是野生型基因的1.61倍。结论携带IL-8基因rs4073位点TT基因型人群罹患高尿酸血症的危险性增加。Objective To investigate the association between the polymorphism of interleukin-8 (IL-8) gene and hyperuricemia in Xinjiang Uygurs.Methods A total of 1 168 Uyghur males,who took physical examination in the First Affiliated Hospital of Xinjiang Medical University,the First Peoples' Hospital of Kashgar,Turpan Hospital and Toli County People's Hospital aged 20-60 years were selected as the study subjects in the minority residential areas.There were 594 cases in the control group and 574 cases in the hyeruricemia group.General physical examinations,uric acid and indicators related with renal function were detected.Taqman probe was used to detect IL-8 gene polymorphisms.The hyperuricemia group had fasting serum uric acid exceeding 417 μmol/L.Results The frequency of genotype distribution and the distribution of allele frequency of rs4073 in IL-8 gene between the hyperuricemia group and the control group were statistically significantly different (P<0.05).The risk of hyperuricemia of variant gene in IL-8 gene rs4073 was 1.61 times greater than that of the wild-type gene.Conclusion There is an increased risk of hyperuricemia among people with TT gene in IL-8 gene rs4073 locus.

关 键 词：高尿酸血症 白细胞介素8 维吾尔族 新疆[维吾尔自治区] 

分 类 号：R589.7[医药卫生—内分泌] R446.112[医药卫生—内科学]