孢子丝菌病原学的研究进展  

Advances in research on pathogenicity of sporotrichosis

作　　者：郭亚南 侴梦微 刘慧瑜[1] GUO Yanan;CHOU Mengwei;LIU Huiyu(Department of Dermatology,First Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院皮肤性病科

出　　处：《临床与病理杂志》2019年第5期1074-1079,共6页Journal of Clinical and Pathological Research

基　　金：黑龙江省青年科学基金(QC2012C028)~~

摘　　要：孢子丝菌病是一种世界性的慢性肉芽肿性真菌病,为人兽共患病,主要由孢子丝菌复合体感染而致病,可引起皮肤、黏膜及淋巴管的炎症。其传染源、传播方式和分布模式因致病菌种的不同而不同。其中,球形孢子丝菌主要引起固定型皮肤病变;巴西孢子丝菌毒性强,是与猫传播的孢子丝菌病最相关的物种。近年来动物感染的病例报道日渐增多,巴西地区也因出现暴发事件而备受国际关注。因此了解病原体的生物学特征以及致病菌种的流行病学特点对于疾病的诊治及预后至关重要。Sporotrichosis is a worldwide chronic granulomatous fungal disease that is zoonotic.It is mainly caused by infection by the sporozoite complex,which can cause chronic infectious inflammation of the skin,mucous membranes and lymphatic vessels.The source of infection,mode of transmission and distribution pattern vary depending on the pathogen.Among them,Sporothrix globosa mainly causes fixed cutaneous lesions.S.brasiliensis has highly toxic and is the most prevalent species related to cat transmitted sporotrichosis.In recent years,case reports of animal infections are increasing,and outbreaks in Brazil have also received international attention. Therefore,understanding the biological characteristics of pathogens and the epidemiological characteristics of pathogenic bacteria are crucial for the diagnosis and treatment of the disease.

关 键 词：孢子丝菌病 病原学 致病菌种的流行病学 免疫应答 

分 类 号：R519[医药卫生—内科学]