内皮素及其受体与缺血性心脏病  

Endothelin and its receptors and ischaemic heart disease

作　　者：陈娟[1] 何东 胡佳 韦星[1] CHEN Juan;HE Dong;HU Jia;WEI Xing(Institute of Cardiovascular Diseases,University of South China&Key Laboratory for Arteriosclerology of Hunan Province,Hengyang Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室

出　　处：《临床与病理杂志》2019年第5期1105-1110,共6页Journal of Clinical and Pathological Research

摘　　要：内皮素(endothelin,ET)是内皮细胞中分离出的一种活性多肽,是迄今所知最强的缩血管物质之一。它不仅存在于血管内皮细胞中,也广泛存在于心脏、大脑、肺和胃肠道系统中,是调节心血管功能的重要因子,并对缺血性心脏病的发生、发展起非常重要的作用。本文对ET及其相关受体的产生及水平,在心脏缺血性病变如缺血-再灌注损伤(ischemia/reperfusion injury,I/R)、心肌无复流、室性心率失常等中的作用作一综述。Endothelin is an active polypeptide isolated from endothelial cells and the strongest vasoconstrictor known to date.It not only exists in vascular endothelial cells,but also widely exists in the heart,brain,lung and gastrointestinal system.It is one of the most important factors regulating cardiovascular function,and plays a very important role in the occurrence and development of ischemic heart disease.This article reviews the production and level of endothelin and its related receptors in ischemic heart disease,such as ischemia-reperfusion injury,noreflow, ventricular arrhythmia and so on,and looks forward to its application prospects.

关 键 词：内皮素 缺血-再灌注损伤 心肌无复流 室性心律失常 

分 类 号：R541[医药卫生—心血管疾病]