慢性阻塞性肺疾病并肺性脑病的患者早期应用无创呼吸机联合尼可刹米治疗的疗效分析  

Therapeutic Effect of Early Noninvasive Ventilator Combined with Nikethamide in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Encephalopathy

作　　者：马文文[1] 孙善雷 张志国[1] 张燕妮 邵芳 MA Wen-wen;SUN Shan-lei;ZHANG Zhi-guo;ZHANG Yan-ni;SHAO Fang(Department of Respiratory Medicine,Jinxiang County People's Hospital,Jinxiang,Shandong Province,272200 China)

机构地区：[1]山东省金乡县人民医院呼吸内一科,山东金乡272200

出　　处：《系统医学》2019年第7期7-9,共3页Systems Medicine

摘　　要：目的分析慢性阻塞性肺疾病并肺性脑病的患者早期应用无创呼吸机联合尼可刹米治疗的疗效。方法选取该院于2016年1月—2018年8月诊治的100例慢性阻塞性肺疾病合并肺性脑病患者,随机纳入治疗组和对照组,对照组实施无创呼吸机治疗,治疗组应用无创呼吸机联合尼可刹米治疗,对比临床疗效。结果在接受治疗后24 h,48 h两组患者PaO_2、PaCO_2水平有所改善,治疗组患者接受治疗后PaCO_2 24 h治疗指标(50.6±3.2)mmHg,48 h指标(43.2±2.5)mmHg;与对照组PaO_2 24 h治疗指标(69.9±3.7)mmHg,48 h指标(54.9±3.7)比较(t=12.283、11.093,P<0.05)。治疗组患者接受治疗后PaO_224 h治疗指标(83.9±2.8)mmHg,48 h指标(93.4±3.6)mmHg;与对照组PaO_224 h治疗指标(70.6±3.2)mmHg,48 h指标(74.1±2.1)mmHg比较(t=11.893,10.156,P<0.05)。治疗组患者的气管插管率、并发症发生率均低于对照组,且获得了更高的治疗有效率,组间数据互比可见差异有统计学意义(χ~2=11.293、10.972、8.926,P<0.05)。结论慢性阻塞性肺疾病合并肺性脑病应用无创呼吸机联合尼可刹米治疗,能够增强患者的治疗效果,促进症状、体征改善,及早减轻痛苦。Objective To analyze the efficacy of early noninvasive ventilator combined with nikethamide in patients with chronic obstructive pulmonary disease and pulmonary encephalopathy. Methods 100 patients with chronic obstructive pulmonary disease complicated with pulmonary encephalopathy who were treated in our hospital from January2016 to August 2018 were randomly selected into the treatment group and the control group. The control group was treated with non-invasive ventilator, and the treatment group with non-invasive ventilator combined with nikethamide treatment, comparing clinical efficacy. Results The levels of PaO2 and PaCO2 were improved in the two groups at 24 hours and 48 hours after treatment. The treatment group received PaCO224 hours of treatment(50.6±3.2)mmHg and 48 hours(43.2 ±2.5)mmHg, PaO224 hours treatment index(69.9 ±3.7)mmHg, 48 hours index(54.9 ±3.7)mmHg(t =12.283,11.093, P <0.05). The treatment group received PaO224 hours treatment index(83.9 ±2.8)mmHg and 48 hours index(93.4±3.6)mmHg after treatment. Compared with the control group PaO224 hours treatment index(70.6±3.2)mmHg, 48 hours index(74.1±2.1)mmHg(t=11.893,10.156, P<0.05). The tracheal intubation rate and complication rate of the treatment group were lower than those of the control group, and higher treatment efficiency was obtained. The statistical difference between the data of the groups was observed(χ^2=11.293, 10.972, 8.926, P<0.05). Conclusion The treatment of chronic obstructive pulmonary disease with pulmonary encephalopathy using non-invasive ventilator combined with nikethamide can enhance the patient’s therapeutic effect, promote the improvement of symptoms and signs, and relieve pain early.

关 键 词：慢性阻塞性肺疾病 肺性脑病 无创呼吸机 尼可刹米 

分 类 号：R714[医药卫生—妇产科学]