左旋甲状腺素片治疗妊娠合并甲状腺功能减退的疗效分析  

Therapeutic Effect of Levothyroxine Tablets on Pregnancy with Hypothyroidism

作　　者：赵文[1] ZHAO Wen(Fangshan District Hospital of Traditional Chinese Medicine,Beijing,102400 China)

机构地区：[1]北京市房山区中医院,北京102400

出　　处：《系统医学》2019年第7期115-117,共3页Systems Medicine

摘　　要：目的观察左旋甲状腺素片治疗妊娠合并甲状腺功能减退的疗效。方法收集研究对象为医院2014年5月—2018年5月确诊的106例妊娠合并甲状腺功能减退患者,按照简易随机法分为两组,对照组52例应用甲状腺素片,观察组54例在常规治疗基础上结合左旋甲状腺素片治疗,对比不同方法治疗效果。结果观察组治疗后的FT3(3.48±1.25)pmol/L、FT4(10.22±4.20)pmol/L、TSH水平(6.00±1.44)mIU/L改善优于对照组FT3(1.36±0.49)pmol/L、FT4(7.44±2.17)pmol/L、TSH水平(6.17±1.50)mIU/L,观察组剖宫产率(22.22%)、新生儿窒息(3.70%)、胎死宫中(0.00%)、极低体质量儿发生率(7.41%)少于对照组剖宫产率(63.46%)、新生儿窒息率(15.38%)、胎死宫中(11.54%)、极低体质量儿(23.08%)(χ~2=18.44、4.23、6.60、5.08,P<0.05),妊娠并发症(糖代谢异常3.70%以及高血压发生率1.85%)少于对照组(26.92%)、(23.08%)(χ~2=7.50、7.41,P<0.05),治疗总有效率96.30%高于对照组50.02%(χ~2=29.21,P<0.05)。差异有统计学意义(P<0.05)。结论左旋甲状腺素片治疗妊娠合并甲状腺功能减退,可改善妊娠结局以及新生儿预后,临床应用价值显著。Objective To observe the efficacy of levothyroxine tablets in the treatment of pregnancy with hypothyroidism. Methods A total of 106 pregnant women with hypothyroidism who were diagnosed in the hospital from May 2014 to May 2018 were enrolled. The patients were divided into two groups according to the simple randomization method. 52 patients in the control group were treated with thyroxine tablets, and 54 patients in the observation group were included. On the basis of conventional treatment, combined with levothyroxine tablets, the therapeutic effects of different methods were compared. Results The FT3(3.48±1.25) pmol/L, FT4(10.22±4.20) pmol/L, and TSH levels(6.00±1.44) m IU/L improved in the observation group compared with the control group FT3(1.36±0.49) pmol/L, FT4(7.44±2.17)pmol/L, TSH level(6.17±1.50)mIU/L, observation group cesarean section rate(22.22%), neonatal asphyxia(3.70%), fetal death in the palace(0.00%), the incidence of very low body mass(7.41%) was lower than that of the control group(63.46%), neonatal asphyxia rate(15.38%), fetal death(11.54%), very low body weight(23.08%)(χ^2=18.44, 4.23, 6.60, 5.08, P<0.05), pregnancy complications(abnormal glucose metabolism 3.70% and hypertension incidence rate 1.85%) were less than the control group(26.92%),(23.08%)(χ^2=7.50, 7.41, P<0.05), the total effective rate of treatment was 96.30% higher than that of the control group 50.0%(χ^2=29.21, P<0.05).the difference was statistically significant(P<0.05) Conclusion L-thyroxine tablets in the treatment of pregnancy with hypothyroidism can improve pregnancy outcomes and neonatal prognosis, clinical value is significant.

关 键 词：左旋甲状腺素片 妊娠 甲状腺功能减退 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]