干扰素诱导单核因子和干扰素诱导蛋白10水平与颈动脉内膜中膜厚度的相关性  

Correlation of serum levels of monokine induced by interferon-γ and interferon-γ-inducible protein-10 with carotid intima-media thickness

作　　者：马刘佳[1] 康平 宋彦彬[2] MA Liu-Jia;KANG Ping;SONG Yan-Bin(Department of Neurosurgery, Yanan University Affiliated Hospital, Yanan,Shanxi 716000,China)

机构地区：[1]延安大学附属医院神经外科,陕西省延安市716000 [2]榆林市第一医院神经外科,陕西省榆林市718000

出　　处：《国际神经病学神经外科学杂志》2019年第2期132-135,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨干扰素诱导单核因子(MIG)和干扰素诱导的蛋白10(IP-10)水平与颈动脉内膜中膜厚度(IMT)的相关性.方法对研究纳入的164例患者进行临床基线特征测定和随访观察,并记录患者IMT值以及MIG和IP-10血清水平;分析MIG和IP-10血清水平与IMT之间的关系。结果 IMT最大值0.991±0.127 mm,平均值0.796±0.136 mm。血清MIG和IP-10水平与颈动脉IMT呈显著正相关;血清MIG或IP-10水平与随访期间IMT的变化无显著相关性。当调整混杂因素和药物因素后,血清MIG独立与颈动脉IMT相关(max-IMT:β=0.198,P=0.010;mean-IMT:β=0.186,P=0.017)。结论血清MIG水平与颈动脉IMT具有独立相关性,这可能预示着血清MIG水平检测在早期动脉粥样硬化诊断方面的潜在临床意义。Objective To evaluate the correlation of the levels of monokine induced by interferon-γ( MIG) and interferon-γ-inducible protein-10( IP-10) with carotid intima-media thickness( IMT). Methods A total of 164 patients were enrolled as subjects. Clinical and follow-up studies of baseline characteristics,IMT,and serum levels of MIG and IP-10 were performed among those patients. The relationship of serum levels of MIG and IP-10 with carotid IMT was analyzed. Results The maximum and mean values of IMT were 0. 991 ± 0. 127 mm and 0. 796 ± 0. 136 mm,respectively. The serum levels of MIG and IP-10 were positively correlated with carotid IMT. No significant correlation could be demonstrated of the serum levels of MIG or IP-10 with the changes in IMT during follow-up.After correction for confounding and drug factors,the serum level of MIG was independently correlated with carotid IMT( max-IMT: β= 0. 198,P = 0. 010;mean-IMT: β = 0. 186,P = 0. 017). Conclusions Serum MIG level is independently correlated with carotid IMT,suggesting that the serum Mig level probably has potential clinical significance in the early diagnosis of atherosclerosis.

关 键 词：动脉粥样硬化 干扰素诱导单核因子 干扰素诱导蛋白10 颈动脉内膜中膜厚度 

分 类 号：R543.4[医药卫生—心血管疾病]