胃左动脉联合食管固有动脉化疗栓塞治疗中晚期贲门癌的疗效  

The curative effect of additional proper esophageal artery chemoembolization in treating advanced cardiac carcinomas

作　　者：李方正[1] 任建庄[1] 韩新巍[1] 陈鹏飞[1] 许琳惠 万里 王家兴 LI Fangzheng;REN Jianzhuang;HAN Xinwei;CHEN Pengfei;XU Linhui;WAN Li;WANG Jiaxing(Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, China)

机构地区：[1]郑州大学第一附属医院放射介入科,450052

出　　处：《介入放射学杂志》2019年第5期472-475,共4页Journal of Interventional Radiology

摘　　要：目的观察分析胃左动脉联合食管固有动脉化疗栓塞治疗中晚期贲门癌临床价值。方法回顾性分析自2015年3月至2017年12月收治的52例中晚期贲门癌患者,其中25例采用贲门癌胃左动脉灌注化疗药物并栓塞(称常规组),联合组27例在常规组基础上追加食管固有动脉灌注化疗栓塞。术后定期复查上消化道造影、上腹部CT等。采用Kaplan-Meier法计算生存时间,Log-rank检验比较2组患者的生存曲线。结果患者随访3～27个月,术后常规组总缓解率达48%,联合组总缓解率达77.8%,吞咽困难改善程度联合组优于常规组,差异有统计学意义(P<0.05)。常规组中位生存期为12个月,6、12、18、24个月生存率分别为76%(19/25)、48%(12/25)、16%(4/25)、0,联合组中位生存期为17个月,6、12、18、24个月生存率分别为92.6%(25/27)、77.8%(21/27)、37%(10/27)、7.4%(2/27),生存曲线的差异有统计学意义(Log-rank检验,χ~2=5.973,P<0.05)。结论胃左动脉联合食管固有动脉灌注化疗栓塞治疗中晚期贲门癌较单纯胃左动脉灌注化疗栓塞能更有效地控制肿瘤病灶发展、改善患者症状,延长生存期,在临床治疗中有一定价值。Objective To analyze the clinical value of additional proper esophageal artery chemoembolization in treating advanced cardiac carcinomas. Methods The clinical data of 52 patients with advanced cardiac carcinoma, who were admitted to authors’ hospital during the period from March 2015 to December 2017 to receive treatment, were retrospectively analyzed. The patients were divided into routine group(n=25, receiving left gastric artery infusion of chemotherapeutic drugs and embolization) and combination group(n=27, receiving additional proper esophageal artery chemoembolization on the basis of the treatment used in the routine group). After the treatment, upper gastrointestinal radiography, upper abdominal CT scan, etc. were periodically reexamined. Using Kaplan-Meier method to calculate the survival time, and Log-rank test was used to compare the survival curve between the two groups. Results All the patients were followed up for 3-27 months. The postoperative overall remission rates in the routine group and the combination group were 48% and 77.8% respectively. The improvement degree of dysphagia in the combination group was much better than that in the routine group, the difference between the two groups was statistically significant(P<0.05). In the routine group, the median survival was 12 months, and the 6-, 12-,18-, and 24-month overall survival rates were 76%(19/25), 48%(12/25), 16%(4/25) and 0%(0/25)respectively. In the combination group, the median survival was 17 months, and the 6-, 12-, 18-and 24-month overall survival rates were 92.6%(25/27), 77.8%(21/27), 37%(10/27) and 7.4%(2/27) respectively.The difference in survival curve between the two groups was statistically significant(using Log-rank test,χ~2=5.973, P<0.05). Conclusion For the treatment of advanced cardiac carcinomas, left gastric artery infusion chemoembolization combined with proper esophageal artery chemoembolization is superior to simple left gastric artery infusion chemoembolization in more effectively controlling the development of tumo

关 键 词：中晚期贲门癌 灌注化疗栓塞 食管固有动脉 

分 类 号：H735.3[语言文字]