干细胞治疗慢性肾脏病的研究进展  

Research progress in stem cell therapy for chronic kidney diseases

作　　者：杨素萍 张文卿 杨扬[1] 吴思颖 韩磊[1] 王家平[1] YANG Suping;ZHANG Wenqing;YANG Yang;WU Siying;HAN Lei;WANG Jiaping(Department of Radiology, Affiliated Second Hospital of Kunming Medical University, Kunming, Yunnan province 650101, China)

机构地区：[1]昆明医科大学附属第二医院放射科,650101

出　　处：《介入放射学杂志》2019年第5期494-498,共5页Journal of Interventional Radiology

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项项目(2017FE467-067)

摘　　要：慢性肾脏病是一类具有高发病率、高致死率的全球性疾病。目前慢性肾脏病的主要治疗方法是肾脏替代疗法,即维持性透析治疗和肾移植,然而这两种方法均存在一定局限性。干细胞作为一类具有自我更新、多分化潜能的细胞,为慢性肾脏病的治疗提供了新方向,本文对胚胎干细胞、诱导多能干细胞、成体干细胞治疗慢性肾脏病的研究现状进行论述,同时总结了介入技术在干细胞移植治疗慢性肾脏病中的应用,将介入技术与干细胞移植有效结合,促进介入技术的发展,也为干细胞的进一步研究提供参考。Chronic kidney disease(CKD) is a worldwide disease with high morbidity and mortality. At present, the main treatment for CKD is renal-replacement therapy, including maintenance dialysis treatment and kidney transplantation. However, renal-replacement therapy has certain limitations. As a kind of cells with self-renewal and multiple differentiation potential, the stem cells provide new therapeutic directions for the treatment of CKD. In this paper, the current research status of embryonic stem cell(ESC), induced pluripotent stem cell(i PSC) and somatic stem cell(SSC) therapy for CKD is reviewed. At the same time, the application of interventional technique in the treatment of CKD with stem cell transplantation is summarized.The effective combination of interventional technique and stem cell transplantation can promote the development of interventional technique and provide reference for further research of stem cells.

关 键 词：慢性肾脏病 胚胎干细胞 诱导多能干细胞 成体干细胞 介入治疗 

分 类 号：R289.5[医药卫生—方剂学]