不同剂量瑞舒伐他汀钙对老年冠心病合并高脂血症患者的有效性和安全性分析  

Efficacy and safety of different doses of Rosuvastatin calcium in treating elderly patients with coronary heart disease complicated with hyperlipidemia

作　　者：郭丽娟[1] 陆芳[1] 扈晓霞[1] 李勇[1] 闫小菊[1] Guo Lijuan;Lu Fang;Hu Xiaoxia;Li Yong;Yan Xiaoju(Department of Cardiology,Harrision International Peace Hospital,Hengshui 05300,China)

机构地区：[1]河北省衡水市哈励逊国际和平医院心内科,053000

出　　处：《中华老年医学杂志》2019年第5期513-515,共3页Chinese Journal of Geriatrics

基　　金：衡水市科学技术局基金资助项目(13008A).

摘　　要：摘要目的探讨不同剂量瑞舒伐他汀钙对老年冠心病合并高脂血症的有效性和安全性。方法选取2015年1月至2017年12月我院收治的130例老年冠心病合并高脂血症患者,按照随机数字表法将其分为对照组(65例)和研究组(65例),对照组患者予10mg/d,研究组给予20mg/d,比较两组患者疗效、治疗前后血脂水平以及不良反应发生率。结果显效、有效和无效研究组分别为25例、35例和5例;对照组分别为21例、31例和13例患者;临床治疗总有效率分别为92.3%和80.0%(χ^2=4.127,P=0.042);治疗后研究组患者TC、TG和LDL-C水平低于治疗前和对照组(均P=0.000);对照组患者恶心呕吐和肌肉酸痛各1例;研究组患者恶心呕吐2例、皮疹2例、肌肉酸痛1例和关节疼痛2例;研究组和对照组患者不良反应发生率分别为10.8%和3.1%,两者比较差异无统计学意义(χ^2=2.984,P=0.084)。结论大剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症临床疗效明显,能显著改善其血脂水平,且不良反应发生率两组比较差异无统计学意义。Objective To investigate the efficacy and safety of different doses of Rosuvastatin calcium in treating elderly patients with coronary heart disease complicated with hyperlipidemia. Methods A total of 130 patients with coronary heart disease in combination with hyperlipidemia admitted into our hospital from January 2015 to December 2017 were enrolled.They were randomly divided into the control group(with Rosuvastatin calcium 10 mg per day, n=65)and the study group(with Rosuvastatin calcium 20 mg per day, n=65). Clinical efficacy, changes of blood lipid levels and adverse reactions after treatment were compared between the two groups. Results In the study group, 25 cases had obvious effects, 35 cases had effects and 5 cases had no effect.In the control group, 21 cases with obvious effects, 31 cases with effects and 13 cases without effect were found.The total effective rates were 92.3% in the study group and 80.0% in control group(χ^2=4.127, P=0.042). The blood levels of total cholesterol(TC), triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the study group were decreased in post-vs.pre-treatment, and were lower in treatment group than in control group(all P=0.000). Nausea and vomiting in 1 case, and muscle ache in 1 case were found in the control group.In the study group, 2 cases of nausea and vomiting, 2 cases of skin rash, 1 case of muscle ache, and 2 cases of joint ache were found.The incidences of adverse reactions were 10.8% and 3.1% in the study and control group respectively, with no significant difference between the two groups(χ^2=2.984, P=0.084). Conclusions The high-dose of Rosuvastatin calcium(20 mg daily)has significant clinical efficacy and improve the blood lipid levels in elderly patients with coronary heart disease complicated with hyperlipidemia, with no significant difference in incidence of adverse reactions between 10 mg daily versus 20 mg daily Rosuvastatin calcium.

关 键 词：冠心病 高脂血症 

分 类 号：R541.4[医药卫生—心血管疾病] R589.2[医药卫生—内科学]