子痫前期对子代远期不良影响  

Long-term adverse effects of preeclampsia on offspring

作　　者：吕莉娟[1] 段红丽[2] 李慧[2] 尹爱华[1] Lyu Lijuan;Duan Hongli;Li Hui;Yin Aihua(Medical Genetics Center, Guangdong Women and Children Hospital, Guangzhou 511400, China;Department of Obstetrics, Guangdong Women and Children Hospital, Guangzhou 511400, China)

机构地区：[1]广东省妇幼保健院医学遗传中心,广州511400 [2]广东省妇幼保健院产科,广州511400

出　　处：《中华围产医学杂志》2019年第5期357-360,共4页Chinese Journal of Perinatal Medicine

基　　金：国家重点研发计划生殖健康及重大出生缺陷防控重点项目(2016YFC1000703).

摘　　要：子痫前期除引起早产、低出生体重、宫内窘迫等并发症,还对子代产生远期影响,可增加其成年子代谢性疾病、心血管疾病、神经发育异常等多种慢性疾病的易感性,并可增加其女性子代发生子痫前期的风险。子痫前期对子代远期健康影响的研究有助于理解子痫前期的病理生理机制,并在生命早期及时干预,以期降低以上慢性疾病的发生。An adverse intrauterine environment due to preeclampsia can not only lead to premature birth, low birth weight and fetal intrauterine distress, but also have long-term impacts on the fetus, such as increasing their susceptibility to metabolic, cardiovascular and neurological disorders. It also increases the risk of preeclampsia in female offspring. Researches focusing on the long-term effects of preeclampsia on the future generation is helpful to understand the pathophysiological mechanism of preeclampsia and to provide timely interventions in early life to reduce the occurrence of chronic diseases in later life.

关 键 词：子痫前期 代谢疾病 心血管疾病 神经发育障碍 疾病易感性 

分 类 号：R714.244[医药卫生—妇产科学]