双心治疗对慢性心力衰竭合并焦虑抑郁患者血清CT-1 S100B的影响  

Effect of double heart therapy on serum CT-1 and S100B in patients with chronic heart failure complicated with anxiety and depression

作　　者：魏旭明[1] 焦全德[1] 任明芬[1] Wei Xuming;Jiao Quande;Ren Mingfen(Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan,China)

机构地区：[1]新乡医学院第二附属医院,河南新乡453002

出　　处：《临床心身疾病杂志》2019年第3期17-20,51,共5页Journal of Clinical Psychosomatic Diseases

基　　金：河南省高等学校重点科研项目(编号16B320018);河南省医用组织再生重点实验室开放课题(编号KFKT15007);河南省教育厅科技攻关项目(编号2007320028).

摘　　要：目的探讨双心治疗对慢件心力衰竭合并焦虑抑郁患者血清心肌营养素-1及S100B蛋白的影响。方法将60例慢性心力衰竭合并焦虑抑郁患者按随机数字表法分为两组,每组30例。所有患者均应用利尿剂、硝酸酯、血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂、β-阻滞剂等,观察组在上述治疗基础上联合舍曲林治疗,观察2周。分别于治疗前后,应用焦虑自评量表、抑郁自评量表评定焦虑、抑郁状况,行心脏彩超测定患者左室舒张末期内径及左室射血分数,并抽血检测患者血清心肌营养素-1、S100B蛋白、氨基末端脑钠肽前体水平,比较两组疗效,并行心肌营养素-1、S100B蛋白、氨基末端脑钠肽前体与抑郁自评量表评分相关分析。结果治疗前两组各项指标比较差异无统计学意义(P>0.05)。治疗后观察组焦虑自评量表、抑郁自评量表评分及心肌营养素-1、S100B蛋白、氨基末端脑钠肽前体较治疗前显著降低(P<0.05或0.01),对照组则无显著变化(P>0.05),观察组显著低于对照组(P<0.01);两组左室舒张末期内径均较治疗前显著降低(P<0.01),左室射血分数较治疗前显著升高(P<0.01),两组间比较差异无统计学意义(P>0.05)。Pearson相关分析显示,慢性心力衰竭合并焦虑抑郁患者血清心肌营养素-1、S100B蛋白、氨基末端脑钠肽前体水平与抑郁自评量表评分呈显著正相关(P<0.01)。结论双心治疗能明显改善慢性心力衰竭合并焦虑抑郁患者的焦虑抑郁症状,降低血清心肌营养素-1及S100B蛋白水平。Objective To observe the effect of double heart therapy on serum CT-1 and S100B in patients with chronic heart failure complicated with anxiety and depression.Methods 60 patients with chronic heart failure complicated with anxiety and depression were randomly divided into two groups,30 cases in each group.All the patients were treated with diuretic,nitrates,angiotensin converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist,beta blocker,and the observation group was treated with sertraline on the basis of the above treatment,patients were observed for 2 weeks.The anxiety and depressive symptoms of two groups were evaluated by self rating Anxiety Scale(SAS)and self rating Depression Scale(SDS)before and after treatment.The left ventricular diastolic diameter(LVDD)and left ventricular ejection fraction(LVEF)were measured before and after treatment in two groups of patients with cardiac color Doppler ultrasound.Blood test serum CT-1,S100B,N-terminal proBNP levels.The efficacy of the two groups was compared,and the correlation between CT-1,S100B,N-terminal proBNP and the self-rating depression scale was analyzed.Results There was no significant difference between the two groups in various indexes before treatment(P>0.05).The scores of SAS and SDS,CT-1,serum S100B,and NT-proBNP were significantly decreased after treatment(P<0.05 or 0.01),there was no significant change in the control group(P>0.05),and the observation group was significantly lower than the control group(P<0.01).The LVDD of the two groups was significantly lower than that before treatment(P<0.01),and the LVEF was significantly higher than that before treatment(P<0.01).There was no significant difference between the two groups(P>0.05).Pearson correlation analysis showed that serum CT-1,S100B,and NT-proBNP levels were significantly positively correlated with SDS scores in patients with chronic heart failure complicated with anxiety and depression(P<0.01).Conclusion Double heart treatment can significantly reduce the levels of serum CT-1 and S10

关 键 词：慢性心力衰竭 心肌营养素-1 S100B蛋白 焦虑自评量表 抑郁自评量表 

分 类 号：R541.6[医药卫生—心血管疾病]