中药汤剂治疗颈动脉粥样硬化患者临床用药规律分析  

Analysis of the rule of traditional Chinese medicine decoction in the treatment of carotid atherosclerosis

作　　者：张文将[1,2] 易健 刘柏炎[1] ZHANG Wenjiang;YI Jian;LIU Baiyan(Hu'nan University of Chinese Medicine, Hu′nan Province, Changsha 410208, China;Pathology Teaching and Research Section, Yiyang Medical College, Hu′nan Province, Yiyang 413000, China;Central Laboratory, the First Hospital of Hu′nan University of Chinese Medicine, Hu′nan Province, Changsha 410007, China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]益阳医学高等专科学校病理教研室,湖南益阳413000 [3]湖南中医药大学第一附属医院中心实验室,湖南长沙410007

出　　处：《中国医药导报》2019年第13期128-131,共4页China Medical Herald

基　　金：湖南省科技计划项目(2018JJ2412);湖南省中医药科研计划项目(201870);湖南省教育厅优秀青年项目(17B271)

摘　　要：目的探索中医药治疗颈动脉粥样硬化的用药规律。方法运用关键词查找的方法在万方、维普、知网数据库上检索2005年1月~2017年12月的文献,最终符合要求的文献共109篇,运用Excel表格建立数据库,并对药物使用的频次、频率、四气、五味、归经、药物类别、治则治法运用SPSS软件进行统计分析。结果文献共使用药物147味,使用频次为1007次。使用频次最高的药物是丹参、川芎、黄芪。药性以温、寒、平为主,累计频率为92.3%;五味以甘、苦、辛为主,累计频率为90.4%;归经以肝、脾、心为主,累计频率为86.4%;药物类别以活血化瘀药、补气药、补血药、温化寒痰药为主,累计频率为45.1%。结论中药汤剂治疗颈动脉粥样硬化以活血化瘀为主。Objective To explore the medication rules of traditional Chinese medicine in the treatment of carotid atherosclerosis. Methods The articles about carotid atherosclerosis were collected by using Wanfang, VIP and CNKI from January 2005 to December 2017. A total of 109 articles were up to the requirements at last. Then the articles were selected and put into software excel to establish a database. The TCM medication rule was analyzed by SPSS statistical software, including the frequency of the drugs being used, rate, four nature of drugs, five flavours, channel tropism, drug category, as well as the therapeutic principle and method. Results Total 147 Chinese herbal medicines were used in the literatures, the total frequency was 1007 times. The most frequently used TCM medications were Radix Salviae Miltiorrhizae, Rhizoma Ligustici Chuanxiong, Radix Astragali seu Hedysari. The main drug properties were warm, calm and cold, the cumulative frequency was 92.3%. The main characters of the five flavors were sweet, bitter, pungent, the cumulative frequency was 90.4%. The main channel tropisms of the drugs were liver, spleen and heart, the cumulative frequency was 86.4%. The main types of drugs were blood-activating and stasis-removing drugs, qi-tonifying drugs, blood-tonifying drugs and warmly resolving cold-phlegm drugs, the cumulative frequency was 45.1%. Conclusion The treatment of carotid atherosclerosis with Chinese medicine decoction is mainly based on activating blood circulation to dissipate blood stasis.

关 键 词：中医药 颈动脉粥样硬化 用药规律 频次 

分 类 号：R543.4[医药卫生—心血管疾病]