全切、次全切术治疗幕上胶质瘤伴癫痫的随机对照研究  

A randomized controlled trial on total resection and subtotal resection for supratentorial gliomas associated with epilepsy

作　　者：汪俊 张杰[1,2] 吴建兵 WANG Jun;ZHANG Jie;WU Jianbing(Department of Neurosurgery,Ya′an People′s Hospital,Sichuan Province,Ya′an 625000,China;Department of Neurosurgery,Chengdu 363 Hospital,Southwest Medical University,Sichuan Province,Chengdu 610041,China)

机构地区：[1]四川省雅安市人民医院神经外科,四川雅安625000 [2]西南医科大学附属成都三六三医院神经外科,四川成都610041

出　　处：《中国医药导报》2019年第14期60-62,共3页China Medical Herald

基　　金：四川省科技支撑计划项目(2011FZ0032)

摘　　要：目的比较全切、次全切术治疗幕上胶质瘤伴癫痫的临床效果。方法选取四川省雅安市人民医院2016年4月~2017年4月收治的56例幕上胶质瘤伴癫痫患者,按照随机数字表法分为观察组与对照组,每组各28例,观察组行肿瘤全切术,对照组则行次全切术,比较两组术后癫痫控制情况、卡氏功能状态(KPS)评分,并发症情况。结果观察组癫痫控制满意率明显高于对照组(P<0.05);观察组术后3个月、1年KPS评分均高于对照组(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论针对幕上胶质瘤伴癫痫患者,采用全切术治疗,效果与次全切术相当,但术中通过处理致病灶,能提高癫痫控制满意率,提高生存质量,减少复发情况,临床应用价值高。Objective To compare the clinical effect of total resection and subtotal resection in the treatment of supratentorial gliomas with epilepsy.Methods A total of 56 patients with supratentorial glioma and epilepsy were admitted to Ya′an People′s Hospital from April 2016 to April 2017,28 cases in each group.Total tumor resection was performed in the observation group and subtotal tumor resection was performed in the control group.Epilepsy control,Karnofsky performance status(KPS)score,complications were compared between the two groups.Results The satisfaction rate of epilepsy control in the observation group was significantly higher than that in the control group(P<0.05),and the KPS score in the observation group at 3 months and 1 year after operation were higher than those in the control group(P<0.05).The complications of the two groups had no statistically significant difference(P>0.05).Conclusion Total resection for supratentorial glioma with epilepsy has the same effect as subtotal resection,but it can improve the satisfaction rate of epilepsy control,improve the quality of life,reduce the recurrence rate and it has high clinical value.

关 键 词：幕上胶质瘤 癫痫 次全切除术 全切除术 

分 类 号：R651[医药卫生—外科学]