山莨菪碱临床应用进展  

Review of Clinical Application of Anisodamine

作　　者：张景媛 吴嘉瑞[1] 周唯[1] 肖浩[2] 李丽嫱[3] 杨庆文[4] 刘晔 成云芳 金有豫[7] 郭思宇 贾珊珊 ZHANG Jingyuan;WU Jiarui;ZHOU Wei;XIAO Hao;LI Liqiang;YANG Qingwen;LIU Ye;CHENG Yunfang;JIN Youyu;GUO Siyu;JIA Shanshan(School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;Dept.of Emergency, the Second Hospital of Hebei Medical University,Hebei Shijiazhuang 050000, China;Dept.of Pediatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;Dept.of Otorhinolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;Dept.of Emergency, the First Affiliated Hospital of Xi’an Medical University,Shaanxi Xi’an 710077, China;Dept.of Medical Affairs, Chengdu the First Pharmaceutical Co., Ltd.,Sichuan Chengdu 611930, China;Basic Medical College, Capital Medical University, Beijing 100069, China)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]河北医科大学第二医院急诊科,河北石家庄050000 [3]首都医科大学附属北京天坛医院儿科,北京100070 [4]首都医科大学附属北京同仁医院耳鼻喉科,北京100730 [5]西安医学院第一附属医院急诊科,陕西西安710077 [6]成都第一制药有限公司医学事务部,四川成都611930 [7]首都医科大学基础医学院,北京100069

出　　处：《中国医院用药评价与分析》2019年第4期385-388,392,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金项目(No.81673829);北京中医药大学与成都第一制药有限公司合作课题

摘　　要：山莨菪碱是从我国特产茄科植物山莨菪中提取分离得到的抗胆碱药,为M胆碱受体阻断剂,在临床上主要被用于治疗感染性休克,平滑肌痉挛,周围血管性疾病(血栓闭塞性脉管炎、糖尿病周围血管病变等),各种神经痛、眩晕病以及眼底疾患(中心性视网膜炎、视网膜动脉血栓)等。本研究通过系统检索中国知网、万方数据库和维普数据库等数据库,对山莨菪碱临床应用文献进行梳理,进而开展综述分析。研究结果显示,山莨菪碱主要用于感染性休克、平滑肌痉挛、眩晕病、急性胰腺炎、结石性肾绞痛和支气管哮喘等疾病;同时,山莨菪碱在糖尿病足、妊娠期高血压疾病、麻醉和内镜检查等方面也有应用。希望本研究可以为山莨菪碱的临床应用和进一步深入研究提供参考和借鉴。Anisodamine is an anticholinergic drug isolated from the Chinese Solanaceae. It is an M choline receptor blocker and is mainly used in the treatment of septic shock, smooth muscle spasm, peripheral vascular disease(thromboangiitis obliterans, diabetic peripheral vascular disease, etc.), various neuralgia, vertigo and fundus diseases(central retinitis, retinal arterial thrombosis). In this study, the clinical application literature of anisodamine was reviewed and analyzed by systematically searching databases such as CNKI, Wanfang database and VIP database. The results showed that anisodamine was mainly used for septic shock, smooth muscle spasm, vertigo, acute pancreatitis, calculous renal colic and bronchial asthma;in the meantime, anisodamine was also used in diabetic foot, gestational hypertension, anesthesia and endoscopy. It is hoped that this study can provide reference for the clinical application and further study of anisodamine.

关 键 词：山莨菪碱 临床应用 综述 

分 类 号：R932[医药卫生—生药学]