2型糖尿病与睡眠障碍  

Type 2 diabetes and sleep disorders

作　　者：蔡璇 程宁 呼延天如 崔素颖[1] 铁璐[1] CAI Xuan;CHENG Ning;HUYAN Tian-ru;CUI Su-ying;TIE Lu(Dept of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191,China;Peking University People′s Hospital, Beijing 100044, China)

机构地区：[1]北京大学基础医学院药理学系,北京100191 [2]北京大学人民医院,北京100044

出　　处：《中国药理学通报》2019年第6期745-747,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81673486);北京市自然科学基金资助项目(No 7172119);国家基础科学人才培养基金(No J1030831/J0108);北京市重点学科基础医学学科建设项目(No BMU20110254)

摘　　要：糖尿病是由多种因素引起的,以慢性高血糖为主要特征的代谢性疾病。近年来,世界范围内糖尿病患者激增,给社会带来了沉重的负担。与此同时,生活方式的改变也导致人群的睡眠质量普遍下降。流行病学和临床研究表明,糖尿病的发生、发展与睡眠障碍关系密切,可能形成恶性循环:一方面,睡眠障碍促进2型糖尿病的发生,影响糖尿病患者血糖的控制;另一方面,糖尿病患者,特别是血糖控制较差者,常常会出现睡眠障碍。该文将基于相关研究,探讨2型糖尿病与睡眠障碍之间的关系,为未来糖尿病的治疗提供新的策略。Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia. Recently, the number of diabetic patients in the world is rapidly growing, which has brought a heavy burden to the society. At the same time, changes in lifestyle lead to a general decline in the quality of sleep in the population. Epidemiological and clinical studies have shown a close relation between the development of diabetes and sleep disorders, which may form a vicious circle. Sleep disorders promote the occurrence of type 2 diabetes and affect the glycemic control of diabetic patients;on the other hand, diabetic patients, especially in poor glycemic control, often have sleep disorders. This review discusses the relationship between type 2 diabetes and sleep disorders based on related research, and may provide new strategies for future treatment of diabetes.

关 键 词：糖尿病 睡眠 阻塞性睡眠呼吸暂停综合症 食欲素 褪黑激素 交感神经系统 

分 类 号：R338.63[医药卫生—人体生理学] R587.1[医药卫生—基础医学]