铁催化合成烯胺酮类化合物  

Synthesis of Enaminone Compounds by Iron-catalyzed

作　　者：方雅莉 Fang Yali(Guangdong Medical University, Dongguan 523808, China)

机构地区：[1]广东医科大学东莞科研中心

出　　处：《广东化工》2019年第10期26-26,35,共2页Guangdong Chemical Industry

摘　　要：烯胺酮类化合物是重要的有机中间体,在药物开发和天然产物的合成中有着重要作用,在现代科学领域中应用广泛。本研究利用了含有不同取代基的酮类化合物作为反应底物,二甲基亚砜为溶剂,与芳香腈在铁离子的催化下反应,以较高的产率生成一系列烯胺酮类化合物。为了得到最佳的反应条件,我们同时探索了溶剂、催化剂、反应时间的不同对反应进度的影响。Enaminone compounds are important organic intermediates, which play an important role in drug development and natural product synthesis. In this study, ketones containing different substituents were used as the reaction substrate, and dimethyl sulfoxide was used as the solvent, the ketones to aromatic nitrile proceeded in the presence by the catalysis of iron to synthesize a series of enaminone compounds at a high yield. In order to obtain the best reaction conditions, we also explored the effect of different solvents, catalysts and reaction time on the reaction progress.

关 键 词：铁 芳香腈 烯胺酮类化合物 

分 类 号：TQ[化学工程]