不同标本来源的表皮葡萄球菌的耐药性分析  

Drug resistance of Staphlococcus epidermidis strains isolated from different clinical specimens

作　　者：周丽萍[1] 郭明秋[1] 郑旭[1] 李迪 陈华波 ZHOU Li-ping;GUO Ming-qiu;ZHENG Xu;LI Di;CHEN Hua-bo(Clinical Laboratory, Qingdao Municipal Hospital, Qingdao, Shandong 266071, China)

机构地区：[1]青岛市市立医院检验科,山东青岛266071 [2]山东省眼科研究所省部共建山东省眼科重点实验室,山东青岛266071

出　　处：《中国卫生检验杂志》2019年第10期1178-1180,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解不同标本来源的表皮葡萄球菌对常用抗菌药物的耐药情况,为临床合理选用抗菌药物提供参考。方法分析2016年-2017年综合医院的血液、尿液、痰液、创面及腹水标本及眼科医院的结摸拭子和角膜刮片标本中分离的表皮葡萄球菌的分布与耐药性,采用WHONET5.6软件分析数据。结果2016年-2017年共分离出病原菌20055株,其中表皮葡萄球菌1059株。表皮葡萄球菌主要来源于结膜、血液和角膜标本,分别占62.1%、12.0%、9.9%。各标本来源表皮葡萄球菌的耐药性普遍较高,尤其对苯唑西林、青霉素、氨苄西林、红霉素的耐药性多在75%以上,对环丙沙星、左氧氟沙星、复方新诺明的耐药性在60%左右。对万古霉素未发现耐药,对阿米卡星、奎奴普丁/达福普汀、利福平、利奈唑胺的耐药率均低于10%。结论不同医院不同标本分离的表皮葡萄球菌的耐药率有差异,临床治疗不同部位表皮葡萄球菌感染性炎症要考虑其耐药性差异。Objective To investigate the distribution and drug resistance of the Staphylococcus epidermidis from several clinical samples, so as to provide guidance for reasonable clinical use of antibiotics. Methods The distribution and drug resistance of the Staphlococcus epidermidis that were isolated from seven specimens ( blood, urine, sputum, wound surface and ascites specimens, as well as nosegay swabs and corneal scraping specimens from eye hospitals) from Jan 2016 to Dec 2017 were statistically analyzed by WHONET 5. 6 software. Results From 2016 to 2017, a total of 20 055 strains of pathogens were isolated, including 1 059 strains of Staphylococcus epidermidis. Staphylococcus epidermidis mainly originated from the conjunctiva, blood and corneal specimens, accounting for 62. 1%, 12. 0%, and 9. 9%, respectively. The resistance of Staphylococcus epidermidis to the specimens was generally high, especially to oxacillin, penicillin, ampicillin, and erythromycin. The resistance to ciprofloxacin, levofloxacin, and cotrimoxazole was higher. The drug resistance was around 60%. No resistance to vancomycin was found, and the resistance rates to amikacin, quinupristin /dalofopine, rifampicin, and linezolid were all less than 10%. Conclusion The Staphlococcus epidermidis strains from different specimens and different hospitals vary in distribution and drug resistance, and it is necessary for clinicians to focus on the resistance difference of Staphlococcus epidermidis.

关 键 词：表皮葡萄球菌 耐药性 标本来源 

分 类 号：R446.5[医药卫生—诊断学]