短角湿生冷水花化学成分的研究  

Chemical constituents from Pilea aquarum subsp.brevicornuta

作　　者：周鹏军 杨国勋 张梦甜 屠娇 温宝莹 丁杰 胡金锋 ZHOU Peng-jun;YANG Guo-xun;ZHANG Meng-tian;TU Jiao;WEN Bao-ying;DING Jie;HU Jin-feng(School of Chemical Engineering,Sichuan University of Science & Engineering,Zigong 643000,China;Department of Natural Products Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]四川轻化工大学化学工程学院,自贡643000 [2]复旦大学药学院天然药物化学教研室,上海201203

出　　处：《天然产物研究与开发》2019年第5期826-831,共6页Natural Product Research and Development

基　　金：国家自然科学基金(81773599);上海科技基金项目(12401901001)

摘　　要：为研究短角湿生冷水花(Pilea aquarum subsp.brevicornuta)化学成分。实验采用色谱法从中分离得到7个化合物,包括5个五环三萜、一个甾醇和一个木脂素。利用波谱学方法鉴定了它们的结构,分别鉴定为pilearbornol(1)、rubiarbonone D(2)、camarolide(3)、表齐墩果酸(4)、齐墩果酮酸(5)、5,8-epidioxy-(3β,5α,8α,22E)-ergosta-6,9(11),22-trien-3-ol(6)和桉脂素(7)。其中,化合物1和2属于乔木萜烷型(arborane)三萜,化合物1为新化合物,化合物2的绝对构型首次通过X-射线单晶衍射得到了确定。所有化合物均为首次从该植物中分离得到,这也是首次从荨麻科植物中分离得到乔木萜烷型三萜化合物。The study was focus on the chemical constituents of Pilea aquarum subsp. brevicornuta and seven compounds were obtained. Their structures were identified as pilearbornol ( 1),rubiarbonone D ( 2),camarolide ( 3),epi-oleanolic acid ( 4), oleanonic acid ( 5),5,8-epidioxy-( 3β,5α,8α,22E)-ergosta-6,9( 11),22-trien-3-ol ( 6) and eudesmin ( 7),respectively,by spectroscopic methods. Among them,compounds 1 and 2 belong to arborane-type triterpenoids and compound 1 is new. In ad- dition,the absolute configuration of compound 2 was determined by X-ray crystal diffraction. All isolates were discovered from this plant for the first time and this is the first time to report arborane triterpenoids from Urticaceae family.

关 键 词：短角湿生冷水花 乔木萜烷 三萜 绝对构型 

分 类 号：R284.2[医药卫生—中药学]