小单胞菌属次级代谢产物及其生物活性研究进展  

Review on secondary metabolites and its biological activities from genus Micromonospora

作　　者：杨星鹏 张志斌[1] 朱笃[1,2] YANG Xing-peng;ZHANG Zhi-bin;ZHU Du(Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi Province,Jiangxi Normal University,Nanchang 330022,China;Key Lab of Bioprocess Engineering of Jiangxi Province, College of life sciences,Jiangxi Science and Technology Normal University,Nanchang 330013,China)

机构地区：[1]江西师范大学生命科学学院江西省亚热带植物资源保护与利用重点实验室,南昌330022 [2]江西科技师范大学生命科学学院江西省生物加工过程重点实验室,南昌330013

出　　处：《天然产物研究与开发》2019年第5期908-915,921,共9页Natural Product Research and Development

基　　金：国家自然科学基金(31760160);江西省教育厅科技项目(GJJ14250);江西师范大学研究生创新项目(YJS2018080)

摘　　要：小单胞菌属(Micromonospora)为稀有放线菌,广泛分布在土壤、海洋和动植物中,其所产代谢产物不仅具有抗菌、抗肿瘤、抗HIV等多种生物活性,而且化学结构新颖多样。本文从化学结构分类、生物活性等方面对近几年已报道的小单胞菌属来源的重要天然产物做了简要综述,以期为小单胞菌天然产物的开发和应用奠定基础。Micromonospora was a rare actinomycete and widely distributed in the soil,sea,animals and plants. Its metabolites not only had anti-microbial,anti-tumor,anti-HIV and other biological activities,but also had novel and diverse chemical struc- tures. Herein,we briefly reviewed the chemical structure and biological activity of natural products from the genus Micromono- spora within the recent years,by which to lay a foundation for future development and application of natural products from Mi- cromonospora.

关 键 词：稀有放线菌 小单胞菌属 次级代谢产物 生物活性 化学结构 

分 类 号：R917[医药卫生—药物分析学] Q936[医药卫生—药学]