PARP家族及临床使用的PARP抑制剂  

PARP Family and Clinically Used PARP Inhibitors

作　　者：王世瑞 薛晓文[1] Wang Shirui;Xue Xiaowen(School of Pharmacy,China Pharmaceutical University,Nanjing 211100,China)

机构地区：[1]中国药科大学药学院

出　　处：《广东化工》2019年第9期134-136,共3页Guangdong Chemical Industry

摘　　要：聚腺苷二磷酸核糖聚合酶(PARP)是一类负责将ADP-核糖基团转移至靶蛋白质从而影响各种细胞过程的蛋白质超家族,在维持基因组稳定性和调节信号通路等方面发挥着不可替代的作用。本文将对PARP的结构亚型和生物学功能方面的研究进展进行综述,并对目前临床上使用的PARP抑制剂作了简要介绍。Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and thereby affect various nuclear and cytoplasmic processes,and they play an irreplaceable role in maintaining genomic stability and regulating signaling pathways.The recent progress in the subtypes and biological functions of PARP was reviewed in this paper,and the PARP inhibitors clinically used was described.

关 键 词：PARP家族 ADP-核糖基化 PARP抑制剂 

分 类 号：TQ[化学工程]