脂联素、骨质疏松与冠心病及其病变严重程度的关系研究  

Relations of Adiponectin and Osteoporosis with Coronary Heart Disease and Its Severity

作　　者：侯剑飞[1] 罗雅月 董能斌[1] 胡大军[2] HOU Jianfei;LUO Yayue;DONG Nengbin;HU Dajun(Department of Functional Inspection Center ,the First People's Hospital of Chenzhou,Chenzhou 423000,China;Department of Cardiovascular Medicine,the First People's Hospital of Chenzhou,Chenzhou 423000,China)

机构地区：[1]湖南省郴州市第一人民医院功能检查中心,423000 [2]湖南省郴州市第一人民医院心血管内科,423000

出　　处：《实用心脑肺血管病杂志》2019年第4期17-21,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：湖南省教育厅科学研究一般项目(16C1491)

摘　　要：背景脂联素是一种脂肪细胞因子,与心血管疾病有关;骨质疏松以骨量减少、骨结构退化为主要病理改变,但目前关于二者与冠心病(CAD)及其病变严重程度的关系鲜有报道。目的探讨脂联素、骨质疏松与CAD及其病变严重程度的关系。方法选取2016年5月-2017年12月就诊于郴州市第一人民医院的CAD患者95例作为病例组,选取同期于本院体检中心体检健康者100例作为对照组。比较两组受试者性别、年龄、体质指数、吸烟史、饮酒史、CAD家族史、脂联素、骨密度;脂联素、骨密度与CAD的关系分析采用多因素Logistic回归分析;脂联素、骨密度与CAD患者Gensini积分、Sullivan积分的相关性分析采用Spearman秩相关分析。结果(1)两组患者性别、年龄、饮酒史、CAD家族史比较,差异无统计学意义(P>0.05);两组患者体质指数、吸烟史、脂联素、骨密度比较,差异有统计学意义(P<0.05)。(2)多因素Logistic回归分析结果显示,脂联素〔OR=5.853,95%CI(2.525,13.570)〕、骨质疏松〔OR=6.284,95%CI(2.972,13.286)〕是CAD的独立影响因素(P<0.05)。(3)Spearman秩相关分析结果显示,脂联素与CAD患者Gensini积分(rs=-0.695)、Sullivan积分(rs=-0.732)呈负相关(P<0.05),骨密度亦与CAD患者Gensini积分(rs=-0.633)、Sullivan积分(rs=-0.587)呈负相关(P<0.05);脂联素与CAD患者骨密度呈正相关(rs=0.573,P=0.024)。结论低脂联素、骨质疏松是CAD的危险因素,且二者均与CAD严重程度呈负相关。Background Adiponectin is one of adipocytokines and is significantly correlated with cardiovascular disease;osteoporosis pathologically characterized by osteopenia and degeneration of bone structure. However,reports about relations of adiponectin and osteoporosis with coronary heart disease and its severity is relatively rare so far. Objective To investigate the relations of adiponectin and osteoporosis with coronary heart disease and its severity. Methods From May 2016 to December 2017 in the First People’s Hospital of Chenzhou,a total of 95 patients with coronary heart disease were selected as case group,meanwhile a total of 100 healthy people admitted to physical examination center were selected as control group.Gender,age,BMI,smoking history,drinking history,family history of coronary heart disease,adiponectin and bone mineral density were compared between the two groups;multivariate Logistic regression analysis was used to analyze the relations of adiponectin and osteoporosis with coronary heart disease;Spearman rank correlation analysis was used to analyze the correlations of adiponectin and bone mineral density with Sullivan score and Gensini score in patients with coronary heart disease. Results(1)No statistically significant difference of gender,age,drinking history,or family history of coronary heart diseasewas found between the two groups(P>0.05),while there was statistically significant difference in BMI,smoking history,adiponectin and osteoporosis between the two groups,respectively(P<0.05).(2)Multivariate Logistic regression analysis results showed that,adiponectin〔OR=5.853,95%CI(2.525,13.570)〕and osteoporosis〔OR=6.284,95%CI(2.972,13.286)〕were independent influencing factors of coronary heart disease(P<0.05).(3)Spearman rank correlation analysis results showed that,adiponectin was negatively correlated with Gensini score(rs=-0.695)and Sullivan score(rs=-0.732)in patients with coronary heart disease,respectively(P<0.05),bone mineral density was also negatively correlated with Gensini score(

关 键 词：冠心病 骨质疏松 脂联素 GENSINI积分 Sullivan积分 影响因素分析 

分 类 号：R541.4[医药卫生—心血管疾病]