盐酸替罗非班在急性心肌梗死急诊PCI中的应用效果  

Application effect of tirofiban hydrochloride in emergency PCI for acute myocardial infarction

作　　者：彭超[1] 吴容 宋林 郑维惟 PENG Chao;WU Rong;SONG Lin;ZHENG Wei-wei(Xingyi People's Hospital,Xingyi 562400,China)

机构地区：[1]贵州省兴义市人民医院

出　　处：《临床医学研究与实践》2019年第15期10-11,44,共3页Clinical Research and Practice

摘　　要：目的分析盐酸替罗非班在急性心肌梗死急诊经皮冠状动脉介入术(PCI)中的应用价值。方法回顾性分析2018年1月至2018年12月在本院接受诊治的94例急性心肌梗死患者的临床资料,将患者根据治疗方式不同分为试验组与常规组,各47例。所有患者均实施急诊PCI治疗,试验组在术前应用盐酸替罗非班治疗。比较两组患者的术后TIMI血流分级情况、左心射血分数及术后30d内心脏不良事件发生情况。结果术后,试验组中TIMI血流分级为Ⅲ级的患者占93.62%,显著高于常规组的80.85%,差异具有统计学意义(P<0.05);试验组患者术后7d的左心射血分数为(63.03±6.96)%,显著高于常规组的(53.51±3.75)%,差异具有统计学意义(P<0.05);试验组的心脏不良事件总发生率明显低于常规组,差异具有统计学意义(P<0.05)。结论替罗非班应用于急性心肌梗死急诊PCI中能够快速改善患者的心脏功能,降低患者心脏不良事件发生率,安全性高。Objective To analyze the application value of tirofiban hydrochloride in emergency percutaneous coronary intervention (PCI) for acute myocardial infarction.Methods The clinical data of 94 patients with acute myocardial infarction treated in our hospital from January 2018 to December 2018 were retrospectively analyzed.The patients were divided into experimental group and conventional group according to different treatment methods, with 47 cases in each group.All patients were given emergency PCI treatment, and tirofiban hydrochloride was used in the experimental group before operation.The TIMI blood flow grading, left ventricular ejection fraction and incidences of adverse cardiac events within 30 days after operation were compared between the two groups.Results The patients with TIMI grade Ⅲ in the experimental group was 93.62%, which was significantly higher than 80.85% of the conventional group, the difference was statistically significant (P<0.05).The left ventricular ejection fraction at 7 days after operation of the experimental group was (63.03±6.96)%, which was significantly higher than (53.51±3.75)% in the conventional group, the difference was statistically significant (P<0.05).The total incidence of adverse cardiac events in the experimental group was significantly lower than that in the conventional group, the difference was statistically significant (P<0.05).Conclusion The tirofiban hydrochloride in emergency PCI for acute myocardial infarction can rapidly improve the cardiac function of patients, reduce the incidence of adverse cardiac events, and with high safety.

关 键 词：盐酸替罗非班 急性心肌梗死 急诊 经皮冠状动脉介入术 

分 类 号：R542.22[医药卫生—心血管疾病]