健脾单元疗法改善强直性脊柱炎患者血小板参数及免疫炎症指标的数据挖掘研究  

Data mining research on improving spleen parameters and immune inflammation indexes in patients with ankylosing spondylitis by spleen unit therapy

作　　者：方妍妍 刘健[2] 忻凌 董文哲 文建庭 万磊[2] 纵瑞凯[2] FANG Yan-Yan;LIU Jian;XIN Ling;DONG Wen-Zhe;WEN Jian-Ting;WAN Lei;ZONG Rui-Kai(Anhui University of Traditional Chinese Medicine Graduate School,Hefei 230038,China)

机构地区：[1]安徽中医药大学研究生院,合肥230038 [2]安徽中医药大学第一附属医院,合肥230031

出　　处：《中国免疫学杂志》2019年第10期1245-1250,共6页Chinese Journal of Immunology

基　　金：安徽省科技攻关项目(1604a0802085);2016年中央引导地方科技发展专项(财教[2016]1188);现代中医内科应用基础与开发研究徽省重点实验室(财教[2016]518);2015年技术创新服务体系专项(财教[2015]1551);中医药行业科研专项(201307001)和安徽高校自科学研究重点项目(KJ2017A281)

摘　　要：目的:应用关联规则、随机行走和统计学方法分析健脾单元疗法(新风胶囊+辨证论治+芙蓉膏)对强直性脊柱炎(AS)患者血小板参数及免疫炎症指标的影响。方法:整理2012年6月至2017年7月安徽中医药大学第一附属医院风湿免疫科AS患者临床诊治资料。依据是否使用院内特色制剂(新风胶囊及芙蓉膏)将患者分为健脾单元组(实验组)和单纯中药组(对照组)。结果:共检索AS患者1110例,实验组435例,对照组490例;两组性别及年龄差异均无统计学意义。②取两组使用频次前20味的中药,以健脾化湿、活血通络、祛风除湿、清热补肾四类为主。③与治疗前相比,实验组PLT、PCT、ESR、CRP、IgA、IgG、C3、C4指标下降,对照组ESR、CRP、IgA、IgG、C3、C4指标下降,两组间比较ESR、CRP、C3实验组下降更明显;差异有统计学意义(P<0.01或P<0.05)。④由关联规则分析得出与指标关联度较高的前三组药物分别为:新风胶囊&茯苓&丹参关联于PLT下降,新风胶囊&茯苓&陈皮关联于CRP下降,新风胶囊&蒲公英&威灵仙关联于ESR下降。⑤聚类分析得出,当欧式距离为20时,可将药物分为4类。⑥随机行走模型评价实验组PLT、PCT、C4、ESR、CRP较对照组改善显著。结论:两组AS患者血小板参数及免疫炎症指标的改善与干预措施均存在长程关联,且健脾单元疗法的改善效果优于单纯中药治疗。Objective: To study the effect of spleen unit therapy (Xinfeng Capsule + Syndrome Differentiation +Hibiscus cream) on platelet parameters and immune inflammation index in patients with ankylosing spondylitis (AS) by using association rules, random walk and statistical methods. Methods: From June 2012 to July 2017 ,the clinical data of AS patients in Department of Rheumatoid Arthritis in the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were collected.Patients were divided into spleen unit group(Experimental group) and pure Chinese medicine group(Control group) according to whether they used self-development characteristic preparation(Xinfeng Capsule and Hibiscus cream) or not. Results: A total of 1 110 AS patients clinical information were retrieved,435 cases in the experimental group and 490 cases in the control group.There was no significant difference in gender and age between the two groups.②Take two groups of Chinese medicines with the first 20 flavors, and use the spleen and dampness,promoting blood circulation for removing obstruction in collaterals,phlegm and dehumidification,and clearing heat and tonifying kidney.③Compared with those before treatment,the indices of PLT,PCT, ESR,CRP,IgA,IgG,C3 and C4 in the experimental group decreased and the indexes of ESR,CRP,IgA,IgG,C3 and C4 decreased in the control group.The decline of ESR,CRP and C3 in experimental group was more obvious.The difference was statistically significant ( P <0.01 or P <0.05).④According to the association rules,the first three groups of drugs with high correlation with the indexes were as follows:Xinfeng Capsule,& Fu Ling & Dan Shen associated with PLT decreased,Xinfeng Capsule & Fu Ling & Chen Pi associated with CRP decreased,Xinfeng Capsule & Pu Gong Ying & Wei Ling Xian associated with ESR decline.⑤Cluster analysis showed that when the European distance was 20,the drugs could be divided into four categories.⑥Random walk model evaluated experimental group of PLT,PCT,C4,ESR,CRP improved more sig

关 键 词：强直性脊柱炎 健脾单元疗法 血小板参数及免疫炎症指标 数据挖掘 随机行走 

分 类 号：R593.23[医药卫生—内科学]