嗜水气单胞菌肠道外临床分离菌的特征及预后因素分析  

Clinical characteristics and prognostic factors analysis of extraintestinal Aeromonas hydrophila

作　　者：朱延焱[1] 丁卉[2] 徐艳艳[1] 潘锋君[1] 田伟强[1] ZHU Yan-yan;DING Hui;XU Yan-yan;PAN Feng-jun;TIAN Wei-qiang(Pharmacy,Lishui Central Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市中心医院药学部,浙江丽水323000 [2]丽水市中心医院检验科,浙江丽水323000

出　　处：《中国卫生检验杂志》2019年第9期1077-1079,共3页Chinese Journal of Health Laboratory Technology

基　　金：丽水市科技计划项目(2016GYX40)

摘　　要：目的了解肠道外感染嗜水气单胞菌的特征及预后相关因素,为临床优化治疗方案提供依据。方法对本院2010年1月-2017年12月感染嗜水气单胞菌的病例资料进行回顾性分析,调查科室分布、耐药性、基础疾病、预后等资料。结果2010年1月-2017年12月,本院共检出肠道外感染嗜水气单胞菌161株,标本来源主要是伤口分泌物、胆汁、痰液等;科室分布主要为骨科、介入科、ICU等;对氨苄西林、氨苄西林/舒巴耐药率为100.00%;对美罗培南、亚胺培南、阿米卡星等敏感率≥90%;对合并基础疾病调查发现,占首位的是恶性肿瘤,其次是肝胆系统疾病;引起死亡的感染部位是伤口感染、血流感染与肺部感染,与其他部位感染比较,差异有统计学意义(P<0.05)。结论临床医师应了解嗜水气单胞菌的感染特点及预后风险,区别对待,参考药敏选药并加强监测。Objective To investigate the clinical characteristics and prognostic factors of Aeromonas hydrophila in extraintestinal infection,in order to provide basis for optimal therapy. Methods The clinical data of Aeromonas hydrophila in extraintestinal infection collected from our hospital during January 2010-December 2017 were analyzed retrospectively. Departmental distribution, drug resistance,underlying disease,prognosis and other data were investigated. Results From January 2010 to December 2017 in our hospital,161 cases of Aeromonas hydrophila in extraintestinal infection were mainly isolated from wound discharge, bile and sputum. And they were mainly distributed in orthopedics department,interventional departments and ICU. The drug resistance rate was 100. 00% to ampicillin and ampicillin /sulbactam. The sensitivity rate was no less than 90% to meropenem, mipenem and Amikacin. The infections usually occurred in patients with malignancy,followed by hepatobiliary system diseases. Pulmonary infection,wound infection and bloodstream infection were of high mortality,and compared with other infections,the difference is statistically significant ( P < 0. 05). Conclusion Clinicians should be aware of its characteristics and prognostic risks,make a difference between them,select medicines according to the antimicrobial susceptibility results and strengthen monitoring research.

关 键 词：嗜水气单胞菌 肠道外感染 抗菌药物 耐药性 

分 类 号：R446.5[医药卫生—诊断学]