血清可溶性白细胞介素2受体与乙型病毒性肝炎患者细胞免疫功能及肝功能的关系  

Relationship of serum soluble interleukin 2 receptor with cellular immune function and liver function in patients with Viral hepatitis B

作　　者：郑建羚 应晓 吴先华 范素青 付方俊 ZHENG Jian-ling;YING Xiao;WU Xian-hua;FAN Su-qing;FU Fang-jun(Clinical Laboratory,Quzhou Hospital of Traditional Chinese Medicine,Quzhou,Zhejiang 324002,China)

机构地区：[1]衢州市中医医院检验科,浙江衢州324002 [2]衢州市迪安检验中心,浙江衢州324002

出　　处：《中国卫生检验杂志》2019年第9期1092-1094,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清中可溶性白细胞介素2受体水平与乙型肝炎患者细胞免疫功能及肝功能的关系。方法选择2015年6月-2016年6月在本院行治疗的乙型肝炎患者120例,采用酶联免疫吸附法检测患者血液中可溶性白细胞介素2受体的水平,流失细胞仪检测外周血T细胞亚群,全自动生化仪检测患者肝功能,根据肝功结果和HBsAg结果分为肝功能正常的HBsAg(+)观察组,肝功能异常伴HBsAg(+)对照组,探讨血清中可溶性白细胞介素2受体与患者细胞免疫及肝功能的关系。结果观察组血清Treg细胞水平明显低于对照组,Th17细胞水平明显高于对照组;观察组血清IL-2、IL-6、sIL-2R水平均明显高于对照组,差异均有统计学意义(P<0.05)。Logistic回归分析结果提示,IL-6、sIL-2R水平、Treg细胞含量是肝损害的独立危险因素(P<0.05)。结论血清中可溶性白细胞介素-2与患者免疫功能和肝功能异常密切相关。Objective To investigate the relationship of serum soluble interleukin 2 receptor level with cell immune function and liver function in patients with Viral hepatitis B. Methods A total of 120 cases in our hospital from July 2014 to July 2015 year were selected for blood test. The level of soluble interleukin-2 receptor in the blood of patients was detected by enzyme - linked immunosorbent assay ( ELISA). The peripheral blood T cell subsets were detected by cytometry,and the liver function of patients was detected by automatic biochemical analyzer. According to the results of liver function and HBsAg,the patients were divided into observation group with normal liver function and control group with abnormal liver function and HBsAg (+). To investigate the relationship of serum soluble interleukin-2 receptor with cellular immunity and liver function in patients. Results The level of serum Treg cells in the observation group was significantly lower than that in the control group,and the level of Th17 cells in the observation group was significantly higher than that in the control group,with the differences statistically significant ( P > 0. 05). Logistic regression analysis showed that IL-6,sIL-2R and Treg cell content were independent risk factors for liver injury ( P < 0. 05). Conclusion The serum soluble white blood cells were closely related to the immune function and liver function abnormality.

关 键 词：可溶性白细胞介素2受体 肝功能损害 免疫功能 炎症因子 

分 类 号：R512.62[医药卫生—内科学]