替加环素治疗危重症老年呼吸机相关性肺炎患者的疗效观察  

Efficacy of Tigecycline in the Treatment of Critically Ill Patients With Ventilator-Associated Pneumonia

作　　者：朱晓飞[1] 苏秀平[1] 王丁超[1] Zhu Xiaofei;Su Xiuping;Wang Dingchao(ICU,Traditional Chinese Medicine of Fuyang City, Puyang 457000,China)

机构地区：[1]濮阳市中医院重症医学科,河南濮阳457000

出　　处：《哈尔滨医药》2019年第2期101-102,共2页Harbin Medical Journal

摘　　要：目的探讨替加环素治疗危重症老年呼吸机相关性肺炎患者的疗效。方法选择我院2015年4月至2018年4月120例患者进行研究,按照接受治疗的不同药物分为两组,各60例,对照组患者使用美罗培南治疗,观察组在对照组用药基础上联合替加环素治疗,比较两组效果。结果观察组治疗后肺部感染控制、ICU住院时间、总住院时间均短于对照组,观察组治疗后IL-6、IL-8、TNF-α炎症指标均低于对照组,观察组治疗后呼吸做功、气道峰压、气道阻力、动态顺应性等呼吸力学指标均低于对照组(P<0.05)。结论联合使用替加环素治疗危重症老年呼吸机相关性肺炎疗效更好。Objective To investigate the efficacy of tigecycline in the treatment of critically ill patients with ventilator-associated pneumonia.Methods A total of 120 critically ill patients with ventilator-associated pneumonia were enrolled in our hospital from April 2015 to April 2018.They were divided into two groups according to the drugs,60 cases in the observation group and 60 cases in the control group.Patients in the control group were treated with meropenem,and the observation group was treated with tigecycline on the basis of the control group,and the effects of the two groups were compared.Results The control of lung infection,ICU stay,and total hospital stay were shorter in the observation group than those in the control group.The IL-6,IL-8 and TNF-αinflammation indexes in the observation group were lower than those in the control group.The respiratory work,airway peak pressure,airway resistance and dynamic compliance respiratory mechanics were lower in the observation group than those in the control group,P<0.05.Conclusion Joint wen tigecycline is effective in the treatment of critically ill patients with ventilator-associated pneumonia.

关 键 词：老年呼吸机相关性肺炎 危重症 替加环素 治疗 

分 类 号：R563.1[医药卫生—呼吸系统]