Highly Regioselective Sequential 1,1-Dihydrosilylation of Terminal Aliphatic Alkynes with Primary Silanes  

作　　者：Zhaoyang Cheng Shipei Xing Jun Guo Biao Cheng Lan-Fang Hu Xing-Hong Zhang Zhan Lu 

机构地区：[1]Deportment of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310058, China [2]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China

出　　处：《Chinese Journal of Chemistry》2019年第5期457-461,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21772171);Zhejiang Provincial Natural Science Foundation of China(No.LR19B020001);Zhejiang University K.P.Chao's High Technology Development Foundation;the Fundamental Research Funds for the Central Universities.

摘　　要：Summary of main observation and conclusion A regioselective double 1,1-hydrosilylation of terminal aliphatic alkynes with primary silanes catalyzed by one cobalt catalyst has been developed. gem-Bis(dihydrosilyl)alkanes containing four silicon-hydrogen bonds are efficiently constructed in an atom-economical man ner. Tolerated substrates include simplest alkyne-ethyne, a complicated drug derivative and various functi on alized terminal aliphatic alkynes. Asymmetric approach using two catalysts is achieved with excelle nt enan tioselectivities to access corresp on ding chiral products. The tra nsformations of Si—H bonds into Si—C, Si—O, and Si —F bonds and the synthesis of enantioriched a-hydroxysilane show synthetic utility.

关 键 词：COBALT DERIVATIVE UTILITY 

分 类 号：O6[理学—化学]