血管生成评价方法和模型研究进展  

Advances in Evaluation Methods and Models on Angiogenesis

作　　者：崔鹤蓉 李红艳[2] 姜文艳 马涛 王鹏龙[1] 雷海民[1] CUI He-rong;LI Hong-yan;JIANG Wen-yan;MA Tao;WANG Peng-long;LEI Hai-min(School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;College of Life Science and Biotechnology, Beijing University of Technology, Beijing 100124, China)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]辽宁中医药大学药学院,辽宁大连116600 [3]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《中国药学杂志》2019年第9期677-681,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81173519,81603256);中央高校基金科研业务项目(2019-JYB-TD005,BUCM-2018-2020,BUCM-2019-JCRC002);北京中医药大学研究生自主课题(2019-JYB-XS-076);北京中医药基础与新药研究重点实验室项目(100102);中华中医药学会青年人才托举工程项目(CACM-2018-QNRCZ-B08)

摘　　要：血管生成(angiogenesis)系指从已有的毛细血管或毛细血管后静脉发展形成新血管的过程。血管生成主要发生在出生后,是许多血管结构形成的基础,参与体内多种生理、病理过程。由于研究对象的特殊性和种属的差异性,某一种模型得到的实验结果未必能在另一种模型上得到确证,目前全面评价受试因素对血管生成的影响一般需要不同模型结果的相互印证。笔者综述了国内外近十年血管生成相关文献,从细胞、组织、整体水平对目前公认度较高的主要评价方法与实验模型进行归纳,以期为血管生成相关药物研发及活性评价提供依据。Angiogenesis, the process of shaping new vessels from existing or posteriorvessels. It occurs mainly after birth and is the basis for the formation of many vascular structures and participates ina variety of physiological and pathological processes.Due to the particularity of the research objects and the diversity of the species, the experimental results obtained from one model may not be confirmed on the other model. At present,the comprehensive evaluation of angiogenesis requires mutual verification of different model results. Herein, this review mainly summarizes the literatures on the evaluation of angiogenesis activity within recent ten years. From three parallel dimensions of cell, tissue, and animal,the up-to-date evaluation methods and angiogenesis models with wide recognitions are reviewed, in order to provide the reference for related drug research and development.

关 键 词：血管生成 实验方法 评价模型 

分 类 号：R965[医药卫生—药理学]