肝损伤动物模型的研究进展  

Progress in animal models of liver injury

作　　者：徐博 田晶 马宁 吴畏难[2] XU Bo;TIAN Jing;MA Ning;WU Wei-nan(Experimental center,Basic Medical College of Jilin Medical College,Jilin Province,Jilin 132013,China;Department of General Surgery,Jilin Central Hospital of Jilin Province,Jilin 132011,China)

机构地区：[1]吉林医药学院基础医学院实验中心,吉林吉林132013 [2]吉林省吉林市中心医院普外科,吉林吉林132011

出　　处：《中国当代医药》2019年第14期38-40,44,共4页China Modern Medicine

基　　金：吉林省教育厅“十三五”科学技术项目(JJKH20180830KJ);吉林省卫生计生科技创新自筹经费项目(2017ZC035);吉林省吉林市科技创新发展计划项目(20163048)

摘　　要：近年来肝病的发病率呈逐年上升趋势,严重影响患者的生存质量。目前寻求治疗肝损伤药物的基础是如何建立疾病的动物模型,本文通过分析近几年有关肝损伤方面的文献,总结急性肝损伤、慢性肝损伤、药物性肝损伤、酒精性肝损伤的造模方法并探讨肝损伤的机制,现作以下综述。In recent years,the incidence of liver disease is increasing year by year,which seriously affects the quality of life of patients. How to establish animal models of diseases is the basis of searching for drugs to treat liver injury,by analyzing the literatures about liver injury in recent years,to summarize the methods of establishing models of acute liver injury,chronic liver injury,drug-induced liver injury and alcoholic liver injury,and to explore the mechanism of liver injury.

关 键 词：肝损伤 急性 慢性 进展 

分 类 号：R965.1[医药卫生—药理学]