鸦胆子药渣的化学成分研究  

Chemical Constituents from the Dregs of Brucea javanica

作　　者：罗应 申海艳[2] 张敏 谭华欣 文红波 申清香[3] LUO Ying;SHEN Hai-yan;ZHANG Min;TAN Hua-xin;WEN Hong-bo;SHEN Qing-xiang(Department of Biochemistry and Molecular Biology,Hengyang Medical College,Hengyang 421001,Hunan,China;Institute of Pathogenic Biology,Hunan Province Cooperative innovation Center for Molecular Target New Drug Study,Hengyang 421001,Hunan,China;Department of Gynaecology and Obstetrics,the Second Affiliated Hospital,University of South China,Hengyang 421001,Hunan,China)

机构地区：[1]南华大学衡阳医学院生物化学与分子生物学教研室,湖南衡阳421001 [2]南华大学病原生物学研究所,湖南省分子靶标新药研究协同创新中心,湖南衡阳421001 [3]南华大学第二附属医院妇产科,湖南衡阳421001

出　　处：《热带亚热带植物学报》2019年第3期294-298,共5页Journal of Tropical and Subtropical Botany

基　　金：湖南省自然科学基金项目(2018JJ3433);湖南省教育厅科学研究项目(17C1399);湖南省卫生计生委科研计划课题项目(C2017016);湖南省分子靶标新药研究协同创新中心开放基金项目(0223-0002-0002000-55)资助~~

摘　　要：为了解鸦胆子(Brucea javanica)药渣的化学成分,从中分离得到了10个化合物,经波谱分析分别鉴定为对羟基苯甲酸(1)、对羟基苯甲醛(2)、3,4-二羟基苯甲酸(3)、3,4-二羟基苯甲醛(4)、松柏醛(5)、芥子醛(6)、3-吲哚甲醛(7)、3-吲哚甲酸(8)、β-谷甾醇(9)和鸦胆苦醇(10)。其中化合物4~6、8为首次从鸦胆子分离得到。In order to understand the chemical constituents of dregs of Brucea javanica, ten compounds were isolated and purified by column chromatography. On the basis of spectral data, their structures were identified as p-hydroxybenzoic acid (1), p-hydroxy-benzaldehyde (2), 3,4-dihydroxybenzoic acid (3), 3,4-dihydroxy- benzaldehyde (4), coniferaldehyde (5), sinapaldehyde (6), 1H-indole-3-carbaldehyde (7), 1H-indole-3-carboxylic acid (8),β-sitosterol (9), and brusatol (10). Compounds 4 -6 and 8 were obtained from B. javanica for the first time.

关 键 词：鸦胆子 药渣 化学成分 

分 类 号：R284.1[医药卫生—中药学]