中药结合西药治疗胃癌患者的临床疗效及对患者肿瘤标志物、免疫功能和生命质量的影响  

Observation on the Clinical Curative Effects of Integrated Medicine in the Treatment of Gastric Cancer and Its Effects on Tumor Markers,Immunity and Life Quality

作　　者：邵杰[1] 刘包欣子[2] 刘沈林[2] Shao Jie;Liubao Xinzi;Liu Shenlin(National TCM Clinical Research Base,Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Department of Medical Oncology,Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]江苏省中医院(南京中医药大学附属医院)国家中医临床研究基地,南京210029 [2]江苏省中医院(南京中医药大学附属医院)肿瘤内科,南京210029

出　　处：《世界中医药》2019年第4期966-969,973,共5页World Chinese Medicine

基　　金：江苏省科学技术厅项目(BM2010597)

摘　　要：目的:探讨中药结合西药对胃癌术后患者的疗效及对其肿瘤标志物、免疫功能和生命质量的影响。方法:选取2014年12月至2017年12月江苏省中医院收治的胃癌患者64例作为研究对象,按照随机数字表法分为观察组与对照组,每组32例。对照组给予FOLFOX4方案化疗,观察组在化疗方案基础上服用中药汤剂。2组化疗均以21 d为1个周期,连续治疗6个周期。比较2组治疗疗效,治疗前后血清肿瘤标志物和免疫功能变化,生命质量各量表评分和不良反应。结果:观察组治疗有效率(75. 00%)高于对照组(46. 87%),差异有统计学意义(P <0. 05)。2组治疗后血清癌胚抗原(CEA)、糖类抗原199(CA199)和糖类抗原125(CA125)水平降低,差异有统计学意义(观察组:t=21. 662、21. 964、16. 706,对照组:t=8. 780、13. 012、9. 984,P <0. 05);观察组治疗后血清CEA、CA199和CA125水平低于对照组,差异有统计学意义(t=13. 992、11. 731、7. 302,P <0. 05)。观察组治疗后CD4^+和CD4^+/CD8^+升高而CD8^+降低,差异有统计学意义(t=7. 582、6. 936、9. 204,P <0. 05);对照组治疗后CD4^+和CD4^+/CD8^+降低而CD8^+升高,差异有统计学意义(t=5. 453、5. 821、11. 297,P <0. 05);观察组治疗后CD4^+和CD4^+/CD8^+高于对照组而CD8^+低于对照组,差异有统计学意义(t=11. 590、16. 718、17. 623,P <0. 05)。观察组生命质量各量表评分高于对照组,差异有统计学意义(P <0. 05)。观察组胃肠道反应、肝肾功能异常、血小板减少和白细胞减少发生率低于对照组,差异有统计学意义(P <0. 05)。结论:中药结合西药治疗胃癌患者疗效明显,可降低血清CEA、CA199和CA125水平,增强免疫功能及改善患者生命质量。Objective: To investigate the clinical curative effects of integrated medicine in the treatment of gastric cancer patients and its effects on tumor markers,immunity and the quality of life. Methods: A total of 64 patients with gastric cancer treated in Jiangsu Province Hospital of Chinese Medicine from December 2014 to December 2017 were selected and divided into the observation group(32 cases)and the control group(32 cases)according to random number table method.The control group received FOLFOX4 chemotherapy,while the observation group were given Chinese medicine decoction in addition to the same chemotherapy.Both groups received 6 courses of treatment,and the length of each course was 21 days.The curative effects,the changes in the levels of serum tumor markers and immunity before and after the treatment,the scores of life quality and the incidence of adverse reactions were compared between the 2 groups. Results: The total effective rate of the observation group(75.00%)was higher than that of the control group(46.87%)( P <0.05).The serum CEA,CA199 and CA125 levels of the 2 groups decreased after the treatment(the observation group: t =21.662,21.964,16.706;the control group: t =8.780,13.012,9.984, P <0.05);the serum levels of CEA,CA199 and CA125 of the observation group were lower than those of the control group( t =13.992,11.731,7.302, P <0.05).After the treatment,the levels of CD4^+ and CD4^+/CD8^+ increased,while the level of CD8^+ decreased( t =7.582,6.936,9.204, P <0.05)in the observation group;in the control group,CD4^+ and CD4^+/CD8^+ decreased while CD8^+ increased( t =5.453,5.821,11.297, P <0.05)after the treatment;after the treatment,the CD4^+ and CD4^+/CD8^+ levels of the observation group were higher than those of the control group,while the level of CD8^+ was lower than that of the control group( t =11.590,16.718,17.623, P <0.05).The scores of life quality of the observation group were higher than those of the control group( P <0.05).The incidence of gastrointestinal reactions,liver and kidney dysf

关 键 词：中药 西药 胃癌 术后 疗效 肿瘤标志物 免疫功能 生命质量 

分 类 号：R242[医药卫生—中医临床基础] R735[医药卫生—中医学]