大三阳和小三阳患者自身抗体的检测结果分析  

Analysis of the detection results of autoantibodies in patients with dasanyang and xiaosanyang

作　　者：李清元[1] 李振燕[1] 滕彦玲[1] Li Qingyuan;Li Zhenyan;Teng Yanling(Department Of Clinical Laboratory, Jilin Central Hospital, Jilin, Jilin, 132011, China)

机构地区：[1]吉林市中心医院检验科

出　　处：《当代医学》2019年第16期78-79,共2页Contemporary Medicine

摘　　要：目的分析比较大三阳和小三阳慢性乙型肝炎患者的自身抗体的检测结果。方法2016年5月至2018年4月,根据430例慢性乙型肝炎患者的乙肝两对半检测结果,将其分为大三阳和小三阳两组。采集患者清晨空腹静脉血4ml,分离血清后,对自身抗体加以检测,检测内容包括ANA、SMA、LC-1、AMA、LKM、SLA和ENA等。结果大三阳组患者ANA、AMA、LKM和LC-1的阳性率分别为90.23%、88.72%、51.13%和81.95%,小三阳组患者以上4项自身抗体的阳性率分别为51.18%、46.80%、18.52%和44.78%。大三阳组ANA等4项自身抗体的阳性率均高于小三阳组,两组比较差异均有统计学意义(P<0.05)。结论大三阳慢性乙型肝炎患者ANA、AMA、LKM和LC-1的阳性率高于小三阳组。Objective To analyze and compare the detection results of autoantibodies in patients with chronic hepatitis b in dasanyang and xiaosanyang. Methods From May 2016 to April 2018, 430 patients with chronic hepatitis b were divided into two groups according to the HBV two-half test results. 4ml of the patients' fasting venous blood was collected in the morning. After the serum was separated, the autoantibodies were tested, including ANA, SMA, lc-1, AMA, LKM, SLA and ENA, etc. Results The positive rates of ANA, AMA, LKM and lc-1 in the three positive groups were 90.23%, 88.72%, 51.13% and 81.95%, respectively. The positive rates of the above four autoantibodies in the three positive groups were 51.18%, 46.80%, 18.52% and 44.78%, respectively. The positive rate of ANA and other four autoantibodies in the big three positive group was higher than that in the small three positive group, and the difference between the two groups was statistically significant (P<0.05). Conclusion The positive rates of ANA, AMA, LKM and lc-1 in patients with chronic hepatitis b were higher than those in patients with minor hepatitis b.

关 键 词：慢性乙型肝炎 大三阳 小三阳 自身抗体 

分 类 号：R512.62[医药卫生—内科学]