噻托溴铵联合舒利迭对COPD急性期并发呼吸衰竭临床效果、肺功能及炎症因子影响  

Influence on Clinical Effect,Pulmonary Function and Inflammatory Factors of Tiotropium Combined with Seretide in Patients with COPD Complicated with Respiratory Failure

作　　者：王琦[1] 冷琦琦 WANG Qi;LENG Qiqi(Suizhou Central Hospital,Suizhou 441300,China)

机构地区：[1]随州市中心医院,湖北随州441300 [2]随州市曾都医院

出　　处：《中外医学研究》2019年第13期38-40,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析急性期COPD并呼吸衰竭联合应用噻托溴铵、舒利迭治疗的临床效果及肺部功能、炎症因子变化。方法:笔者所在医院临床资料采集于2017年12月-2018年12月呼吸内科诊治的70例急性期COPD并呼吸衰竭患者,按不同治疗方案分为两组,每组35例,对照组治疗药物为舒利迭,观察组在其基础上联合药物噻托溴铵治疗,比较两组临床疗效、肺部功能及炎症反应。结果:观察组治疗8周的总有效率94.29%,相较于对照组高(P<0.05);观察组治疗8周后的FEV1(1.56±0.33)L、FVC(2.56±0.45)L、PEFR(3.56±0.88)L/s,相较于对照组均更高(P<0.01);观察组治疗8周的CRP(25.98±3.11)mg/L、PCT(0.08±0.02)μg/L、IL-6(11.21±1.95)ng/L,相较于对照组水平均有所下降(P<0.01)。结论:急性期COPD并呼吸衰竭经噻托溴铵、舒利迭联合治疗后,临床疗效提高,且肺部功能改善,气道炎症缓解,效果显著。Objective:To analyze the clinical effects and changes of pulmonary function and inflammatory factors in patients with acute COPD and respiratory failure combined with Tiotropium Bromide and Seretide.Method:The clinical data of our hospital were collected 70 patients with acute COPD and respiratory failure diagnosed in the department of respiratory medicine from December 2017 to December 2018.According to different treatment options,they were divided into two groups,35 cases in each group.The control group was treated with Seretide.The observation group was treated with the basic combination drug Tiotropium Bromide,and the clinical efficacy,lung function and inflammatory response were compared between the two groups.Result:The total effective rate of the observation group was 94.29%after 8 weeks of treatment,which was higher than that of the control group(P<0.05).The FEV1(1.56±0.33)L,FVC(2.56±0.45)L,PEFR(3.56±0.88)L/s in the observation group after 8 weeks of treatment were higher than those in the control group(P<0.01).The CRP(25.98±3.11)mg/L,PCT(0.08±0.02)μg/L,IL-6(11.21±1.95)ng/L in the observation group were lower than those in the control group after 8 weeks of treatment(P<0.01).Conclusion:In the acute phase of COPD and respiratory failure,the combination of Tiotropium Bromide and Seretide improves the clinical efficacy,improves lung function,and relieves airway inflammation,and the effect is significant.

关 键 词：COPD 急性期 呼吸衰竭 噻托溴铵 舒利迭 肺功能 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统] R563.8[医药卫生—内科学]