肠道微生态对放射治疗的影响与相关机制  

Effect and mechanism of gut microbiota on radiotherapy

作　　者：李婷 王林平 梁婧 LI Ting;WANG Linping;LIANG Jing(Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014 China)

机构地区：[1]山东大学附属千佛山医院肿瘤内科

出　　处：《中国辐射卫生》2019年第2期214-217,共4页Chinese Journal of Radiological Health

基　　金：山东省自然基金项目(ZR2015HL104)

摘　　要：微生态是由定植于人类上皮屏障的共生菌和其他微生物组成的。共生的微生态对人类的生存和健康发挥着重要作用。微生态还参与了肿瘤的发生、发展和扩散过程。新近研究有力证实了微生态尤其是肠道微生态在抗肿瘤反应中和毒性反应的调节中发挥重要作用。肠道微生态影响着治疗所致的免疫原性细胞死亡诱导的免疫反应。本文中我们将聚焦于肠道微生态对放射治疗所致的机体免疫反应及毒性反应的调节作用及具体机制。Microbiota is composed of symbiotic bacteria and other microorganisms that colonize the human epithelial barrier. Symbiotic microbiota plays an important role in human survival and health.The microbiota is also involved in the process of initiation, progression and dissemination of cancer. Recent researches have strongly confirmed that microbiota, particularly gut microbiota, plays an important role in the regulation of anti-tumor response and toxic response. And the gut microbiota affects the immune response induced by treatment-induced immunogenic cell death in anti-cancer therapy. In this review, we will mainly focus on the regulatory effect of gut microbiota on immunomodulatory effects and toxic response induced by radiotherapy and its specificmechanism.

关 键 词：肠道微生态 肿瘤 放射治疗 免疫调节效应 毒性反应 

分 类 号：R815[医药卫生—放射医学]