某地区GH高危人群HSV-2基因检测结果分析  

Analysis of HSV-2 Gene Detection in High risk population of GH in a certain area

作　　者：杨戈[1] 陈明清 崔凡 雍刚[1] 谢震[1] 沈柱 林昭春[1] Yang Ge;Chen Mingqing;Cui Fan;Yong Gang;Xie Zhen;Shen Zhu;Lin Zhaochun(Institute of Dermatology and Venereology,Sichuan Academy of Medical Sciences and Sichuan Provincial Peope's HosPital,Chengdu Sichuan 610072,China;Sichuan Medical and Health Service Guidance Centei,Chengdu Sichuan 610041,China)

机构地区：[1]四川省医学科学院·四川省人民医院皮肤病性病研究所,四川成都610072 [2]四川省医疗卫生服务指导中心,四川成都610041

出　　处：《医药前沿》2019年第14期28-29,共2页Journal of Frontiers of Medicine

摘　　要：目的:分析本地区361例疑似生殖器疱疹(GH)患者单纯疱疹病毒Ⅱ型(HSV-2)脱氧核糖核酸(DNA)检测情况,比较不同性别、年龄和不同季节阳性检出率的差异,为防治HSV-2感染提供参考.方法:对2017年8月-2018年1月在我院.门诊就诊的疑似GH患者,采取实时荧光定量聚合酶链反应检测HSV-2DNA,对检测结果进行统计分析.结果:患者男性占72.30%,女性占27.70%,平均年龄(39.38±13.38)岁,总阳性检出率36.29%,其中男性组阳性检出率34.87%,女性组阳性检出率40.00%,两者差异无统计学意义(P>0.05);不同年龄段阳性检出率不同,但差异无统计学意义(P>0.05);秋季组阳性检出率34.16%,冬季组阳性检出率38.99%,两者差异无统计学意义(P>0.05).结论:本地区HSV-2感染集中于性活跃人群,男女感染比例相当,不同年龄和秋冬两季阳性检出率差异不显著.因此,对所有高危人群及感染性伴侣要随时进行HSV-2的筛查和防治.Objective lb retrospectively analyze the detection Results of heipes simPlex virus-tyPe 2 (HSVJ) deoxyribonucleic acid (DNA) in 361 patients with suspected genital herpes in this area,compare the differences of positive detection rates(PDR) among different gender groups,age groups and season groups,andprovide reference for the prevention and treatment of HSV-2 infection. Methods HSV-2 DNA were detected by realtime fluorescence quantitative polymerase chain reaction in the lesions of suspected genital herpes patients diagnosed in our department from August 2017 to January 2O18.The detection Results were collected for statistical analysis. Results Among 361 patients,72.30% were males and 27.70% were females,whose average age was (39.38±13.38) years old.The PDRs in all patients,male group and female group were 36.29%,34.87% and 40.00%respectivel.There was no significant difference in these between the gender groups (P > 0.05).The PDRs in different age groups were different,but without significant difference (P > 0.05).The PDRs in autumn group and winter group were 34.16%,38.99% respectivelyand there was also no significant difference between them (P > 0.05).Condusion HSV-2 infection is concentrated in the sexually active population in this areaThe proportion of male and female infection is equaLThere is no significant difference in the PDR between autumn and winterlt is still necessary to further strengthen the screening and prevention of HSV-2 among high-risk population and sexual partners of infected patients.

关 键 词：生殖器疱疹 单纯疱疹病毒Ⅱ型 病毒核酸检测 实时荧光定量聚合酶链反应 

分 类 号：R817.93[医药卫生—影像医学与核医学]