硬化性脂膜炎17例临床及组织病理特点  

Clinical and Histopathological Features of 17 Cases of Sclerosing Panniculitis

作　　者：王柳苑 柯吴坚 张晓辉 陈征宇 潘慧清 杨立刚 WANG Liuyuan;KE Wujian;ZHANG Xiaohui;CHEN Zhengyu;PAN Huiqing;YANG Ligang(Dermatology Hospital of Southern Medical University, Guangzhou 510091, China)

机构地区：[1]南方医科大学皮肤病医院

出　　处：《中国皮肤性病学杂志》2019年第6期671-673,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的分析硬化性脂膜炎的临床特征及病理学特点,提高对本病的认识和诊断。方法对17例确诊的硬化性脂膜炎患者的临床表现、组织病理、诊断及治疗进行回顾性分析。结果本组17例患者中男5例,女12例,平均年龄59.29岁,平均病程14个月。皮疹主要累及小腿中下1/3处,临床表现为皮下红色斑块、结节或萎缩性硬化性斑块,可有色素沉着,伴疼痛,部分患者患侧小腿形成“倒置香槟瓶状”外观。所有患者经过病理确诊,病理特征为皮下脂肪间隔胶原增粗、硬化,脂肪小叶微囊形成及脂膜性脂肪坏死。结论硬化性脂膜炎临床容易误诊,确诊主要依靠临床及病理,临床治疗较困难。Objective To analyze the clinical and pathological features of sclerosing panniculitis and to improve the knowledge and diagnosis of sclerosing panniculitis.Methods The clinical manifestations,histopathology,diagnosis and treatment of 17 patients with sclerosing panniculitis were retrospectively analyzed.Results There were 17 patients in this group,including 5 males and 12 females,with an average age of 59.29 years,with an average course of 14 months.The rash mainly involved the lower 1/3 of the lower leg.The clinical manifestations were red patches,nodules or atrophic sclerosing plaques in the subcutaneous with pigmentation and pain.Some patients suffered from the“inverted champagne bottle"appearance.All patients were pathologically diagnosed,characterized by subcutaneous fat septal collagen thickened and sclerotic,fatty lobular microcapsule formation and lipomembranous fat necrosis.Conclusion Sclerosing panniculitis is easily misdiagnosed.Diagnosis relies mainly on clinical features and pathology,and clinical treatment is difficult.

关 键 词：硬化性脂膜炎 脂肪皮肤硬化症 组织病理 治疗 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]