电针百会、四神聪对围绝经期抑郁模型大鼠脑组织中单胺类神经递质的影响  

Effects of Electroacupuncture on Monoamine Neurotransmitters in Perimenopause Depression Model Rats

作　　者：陈倩倩[1] 曹奕[1] 盛红梅 韦晓丽[1] CHEN Qianqian;CAO Yi;SHENG Hongmei;WEIXiaoli(The Second Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230061,China)

机构地区：[1]安徽中医药大学第二附属医院,安徽合肥230061

出　　处：《中医药临床杂志》2019年第5期916-919,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽中医药大学校级自然重点项目(2018zrzd23)

摘　　要：目的:观察电针百会、四神聪对围绝经期抑郁模型大鼠脑组织中单胺类神经递质的影响,探讨其治疗围绝经期抑郁症的作用机理。方法:选用卵巢去势术后孤养并予以慢性轻度不可预见性刺激制作抑郁动物模型80只,随机分为模型组、药物组、假针刺组和电针组,连续治疗2周,通过观察比较大鼠脑组织中的单胺类神经递质含量及行为学变化,研究电针百会、四神聪的作用机制。观察结果:电针组较模型组、假针刺组及药物组能够明显调节模型大鼠脑组织内单胺类神经递质的含量。结论:电针百会、四神聪能够治疗围绝经期抑郁症,其机理可能与调节脑组织中单胺类神经递质水平有关。Objective: To observe the effects of electroacupuncture on monoamine neurotransmitters in perimenopause depression model rats, and to explore the mechanism of electroacupuncture on perimenopause depression.Methods: choose ovarian castration solitary raise and chronic mild postoperative unpredictability to stimulate the production of depression animal model of 80, randomly divided into Model group, drug group, sham acupuncture group and electroacupuncture group, treatment 2 weeks in a row, by observing the rat single amine neurotransmitter levels in the organization and behavior change, including the best and the mechanism of action of four god astute. Observation results: compared with Model group, sham acupuncture group and drug group, electroacupuncture group can significantly adjust the content of monoamine neurotransmitters in the brain tissue of model rats. Conclusion: electroacupuncture of baihui and sishencong can treat perimenopause depression, and the mechanism may be related to the regulation of monoamine neurotransmitter level in brain tissue.

关 键 词：电针 围绝经期抑郁症 单胺类神经递质 

分 类 号：R246.3[医药卫生—针灸推拿学]