干扰素联合利巴韦林气雾剂治疗手足口病患儿的疗效及对免疫功能的影响  

Efficacy of Interferon Combined with Ribavirin Aerosol in the Treatment of Children with Hand,Foot and Mouth Disease and Its Effects on Immune Function

作　　者：应玲文 徐卓妮 宗卿 马倩[2] Ying Lingwen;Xu Zhuoni;Zong Qing;Ma Qian(Tonglu County Maternal and Child Health Hospital,Zhejiang Hangzhou 311500,China;Children's Hospital Affiliated to Medical College of Zhejiang University,Zhejiang Hangzhou 311500,China)

机构地区：[1]桐庐县妇幼保健院,浙江杭州311500 [2]浙江大学医学院附属儿童医院,浙江杭州311500

出　　处：《儿科药学杂志》2019年第6期22-25,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨干扰素联合利巴韦林气雾剂治疗手足口病患儿的疗效以及对T淋巴细胞亚群及Th1、Th2细胞水平的影响,以期为临床治疗提供参考。方法:选取我院2016年10月至2017年10月收治的120例手足口病患儿作为研究对象,按随机数字表法分为观察组和对照组各60例,所有患儿均予以常规对症支持治疗,对照组在此基础上加用利巴韦林气雾剂,观察组在对照组治疗基础上加用干扰素,评价治疗后病毒转阴率、临床有效率、对淋巴细胞亚群及Th1、Th2型细胞水平的影响以及安全性。结果:观察组的病毒转阴率为74. 14%,显著高于对照组的43. 10%,差异有统计学意义(P <0. 05);观察组临床有效率为95. 00%,显著高于对照组的80. 00%(P<0. 05);治疗5 d后,两组患儿的CD4^+细胞水平以及CD4^+/CD8^+均有不同程度升高,且观察组均显著高于对照组(P<0. 05);治疗后观察组Th1细胞水平高于对照组(P<0. 05),Th2细胞水平低于对照组,差异有统计学意义(P<0. 05);观察组Th1/Th2值高于对照组,差异有统计学意义(P<0. 05)。结论:干扰素联合利巴韦林气雾剂治疗手足口病患儿可有效提高病毒转阴率,改善患儿的免疫失衡状态,临床疗效较好,具有较大的应用价值。Objective:To probe into the efficacy of interferon combined with ribavirin aerosol in the treatment of children with hand,foot and mouth disease and its effects on lymphocyte subsets and Th1 and Th2 cell levels,so as to provide reference for clinical treatment.Methods:Totally 120 children with hand,foot and mouth disease admitted into our hospital from Oct.2016 to Oct.2017 were extracted to be divided into the observation group and the control group via the random number table,with 60 cases in each group.All children were given conventional symptomatic support treatment,the control group was treated with ribavirin aerosol on this basis,and the observation group received interferon on the basis of the control group.The effect and safety of virus conversion rate,clinical efficiency,lymphocyte subsets and Th1,Th2 type cell levels were evaluated after treatment.Results:The virus conversion rate of the observation group was 74.14%,significantly higher than that of the control group(43.10%),and the difference was statistically significant(P<0.05).The clinical effective rate of the observation group was 95.00%,significantly higher than that of the control group(80.00%,P<0.05).After treatment of 5 d,CD4^+cells and CD4^+/CD8^+in both groups were increased to different degree,and the observation group was significantly higher than the control group(P<0.05).After treatment,the Th1 cells in the observation group were higher than the control group(P<0.05),and the Th2 cells were lower than the control group,the difference was statistically significant(P<0.05).The Th1/Th2 value in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Interferon combined with ribavirin aerosol in the treatment of children with hand,foot and mouth disease can effectively improve the rate of viral conversion,improve the immune imbalance of children,with better clinical efficacy and greater value.

关 键 词：干扰素 利巴韦林 手足口病 免疫紊乱 T淋巴细胞亚群 

分 类 号：R725.1[医药卫生—儿科]