窄谱中波紫外线联合复方卡力孜然酊治疗150例白癜风的效果及预后观察  

Effects and Prognosis of Narrow-band Ultraviolet Wave Combined with Compound Kaliziran Tincture in the Treatment of 150 Cases of Vitiligo

作　　者：赵蕾[1] ZHAO Lei(Department of Dermatology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第一附属医院皮肤科,河南郑州450052

出　　处：《罕少疾病杂志》2019年第2期74-76,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究窄谱中波紫外线(NB-UVB)联合复方卡力孜然酊(KT)治疗白癜风的效果。方法选取150例白癜风患者为受试对象,依照随机数表将其分为联合组(n=75)与对照组(n=75)。联合组予以NB-UVB照射联合外搽KT治疗,对照组仅予以NB-UVB照射治疗。比较两组患者治疗前及治疗3个月后血清白细胞介素-17(IL-17)水平、皮损区面积、自信心[Rosenberg自信心评分量表(RSES)]变化情况,分析两组治疗效果及治疗过程中不良反应发生情况差异。结果治疗3个月后,两组患者血清IL-17水平、皮损区面积、RSES评分均较治疗前获得明显改善,且联合组改善效果更佳(P均<0.05);联合组患者治疗效果显著优于对照组(P<0.05),而组间不良反应发生率比较则均无统计学意义(P均>0.05)。结论 NB-UVB联合KT方案可安全有效的应用于白癜风治疗。Objective To explore the effecst of narrow-band ultraviolet(NB-UVB)combined with compound Kaliziran tincture(KT)in the treatment of vitiligo.Methods A total of 150 patients with vitiligo were selected as subjects and were divided into combined group(n=75)and control group(n=75)according to the random number table method.Combined group was given NB-UVB irradiation combined with external application of KT,and control group was only treated with NB-UVB.The changes of serum interleukin-17(IL-17)level,skin lesion area and self-esteem[Rosenberg Self-Esteem Scale(RSES)]were compared between the two groups before and after 3 months of treatment.The treatment effects and occurrence of adverse reactions during treatment were analyzed in the two groups.Results After 3 months of treatment,the serum IL-17 level,skin lesion area and RSES score in the two groups were significantly improved compared with those before treatment,and the improvements were better in combined group(all P<0.05).The treatment effects in combined group were significantly better than those in control group(P<0.05),and there was no statistically significant difference in the incidence rate of adverse reactions between the groups(all P>0.05).Conclusion NB-UVB combined with KT regimen can be safely and effectively applied to vitiligo treatment.

关 键 词：窄谱 中波紫外线 复方卡力孜然酊 白癜风 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]