利用靶器官毒性剂量法(TTD)和证据权重分析法(WOE)评估固化飞灰中重金属非致癌健康风险  

Assessment of heavy metal non-carcinogenic health risk in solidified fly ash using TTD and WOE methods

作　　者：刘丽君 韩静磊[1] 钱益斌[2] 张宗尧 郭庶[1] LIU Lijun;HAN Jinglei;QIAN Yibin;ZHANG Zongyao;GUO Shu(South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510655 , China;Hainan Research Academy of Environmental Sciences, Haikou, 570206, China)

机构地区：[1]环境保护部华南环境科学研究所,广州510655 [2]海南省环境科学研究院,海口570206

出　　处：《环境化学》2019年第5期1014-1020,共7页Environmental Chemistry

基　　金：广州市污染防治新技术、新工艺开发项目(PM-zx022-201507-027)资助~~

摘　　要：传统的健康风险评价方法未考虑重金属对多种靶器官的影响及重金属间的相互作用,不能反映重金属真实的风险情况.ATSDR的靶器官毒性剂量法(TTD)和EPA的证据权重分析法(WOE)分别将重金属能够产生效应的靶器官与重金属间的相互作用引入评价过程,对传统评价方法进行修正.基于此,本研究采用了TTD法和WOE法评估了生活垃圾焚烧厂固化飞灰中重金属的非致癌健康风险,并将其与传统的非致癌健康风险评价方法进行比较.结果表明,传统的非致癌健康风险评价方法得出的HI值为0.2084,经TTD法和WOE法修正后的HI值分别为0.5165和0.6717,修正后风险大于传统方法所预测风险,更严格的反映固化飞灰对工人健康的真实风险.Traditional health risk assessment methods do not really reflect the heavy metals risk, because the interactions among heavy metals and their effects on target organs are not taken into account. To solve this problem, the traditional evaluation method was modified by the target organ toxicity dose(TTD) approach of ATSDR and the weight of evidence(WOE) approach of EPA. This study evaluated the non-carcinogenic health risks of heavy metals in solidified fly ash from a municipal solid waste incinerator in South China through the TTD and WOE methods, and the results were compared with that of the traditional method. The results showed that the Hazard Index(HI) values of the traditional health risk method was 0.2084, whereas the value of TTD modified HI and WOE modified HI was 0.5165 and 0.6717. The value of health risks by the TTD and WOE method were higher than that of the traditional method. It could reflect the factual health risk better for male workers in MSWI.

关 键 词：靶器官毒性剂量 证据权重分析 非致癌健康风险 固化飞灰 重金属 

分 类 号：R994.6[医药卫生—毒理学] X503.1[医药卫生—药学]