新型磁性限进分子印迹复合材料的制备及富集性能  

Preparation and Enrichment Properties of Novel Magnetic Restricted Access Media-molecularly Imprinted Composites

作　　者：吴姗姗 魏缠玲 赵丽娟 田央 王霞 龚波林[1] WU Shanshan;WEI Chanling;ZHAO Lijuan;TIAN Yang;WANG Xia;GONG Bolin(School of Chemistry and Chemical Engineering,North Minzu University,Yinchuan 750021,China;Ningxia Entry and Exit Inspection and Quarantine Bureau Comprehensive Technology Center,Yinchuan 750002,China)

机构地区：[1]北方民族大学化学与化学工程学院,银川750021 [2]宁夏出入境检验检疫局综合技术中心,银川750002

出　　处：《高等学校化学学报》2019年第6期1150-1157,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21565001,31271868)资助~~

摘　　要：采用浸渍热解法制备磁性凹凸棒土(MATP),以磺胺二甲氧嘧啶(SDM)为模板分子, 4-乙烯基吡啶(4-VP)为功能单体,采用反相原子转移自由基聚合(RATRP)法在MATP表面包覆印迹聚合物薄膜,得到磁性分子印迹聚合物(MATP-MIPs),最后在MATP-MIPs表面接枝亲水性单体甲基丙烯酸羟乙酯(HEMA),得到新型磁性限进分子印迹复合材料(MATP-RAM-MIPs).采用傅里叶变换红外光谱(FTIR)仪、扫描电子显微镜(SEM)、热重分析(TGA)仪、振动样品磁强计(VSM)和X射线衍射(XRD)仪对材料进行了表征.通过静态水接触角和考马斯亮蓝G-250方法证明材料外表面具有良好的亲水性和排阻蛋白的特性;采用静态和选择性吸附实验证实MATP-RAM-MIPs对SDM具有良好的吸附选择性和较高的吸附容量.将该材料直接用于牛血清中磺胺类药物的富集分离,加标回收率为86.2%~100.6%,相对标准偏差为2.1%~4.2%,可见该材料在复杂样品前处理中具有良好的实际应用价值.The magnetic attapulgite(MATP) was preparrd by pyrolysis method. Then, using sulfadimethoxine(SDM) as template molecule, 4-vinylpyridine(4-VP) as functional monomer, the imprinted layer was coated on the surface of modified MATP via reverse atom transfer radical polymerization(RATRP), getting magnetic molecularly imprinted polymers(MATP-MIPs). Finally, novel magnetic restricted access media-molecularly imprinted composites(MATP-RAM-MIPs) was obtained by grafting hydrophilic monomer hydroxyethyl methacrylate (HEMA) onto the surface of MATP-MIPs. The polymer was characterized by means of Fourier transform infrared(FTIR) spectrum, scanning electron microscope(SEM), thermogravimetric analysis(TGA), vibrating sample magnetometer(VSM) and X-ray diffraction(XRD). The hydrophilicity of MATP-RAM-MIPs and the ability of exclusion of proteins were studied by the water contact angle and Coomassie brilliant blue G-250 method. The adsorption characters of MATP-RAM-MIPs on SDM were studied by adsorption isothermal and selectivity in detail, and MATP-RAM-MIPs were used as solid phase extraction packing to separate and enrichment of SAs from bovine samples. The spiked recoveries were 86.2%-100.6%, and the relative standard deviations(RSD) were 2.1%-4.2%, indicating that this material has application value in the pretreatment of complex samples.

关 键 词：磁性凹凸棒土 反相原子转移自由基聚合 限进分子印迹聚合物 吸附性能 

分 类 号：O657[理学—分析化学]