冷诱导RNA结合蛋白的调控与功能研究进展  

Research progress in regulation and function of cold induced RNA binding protein

作　　者：王晓慧[1] 徐孝娜[1] 秦绪军[1] 王枫[1] WANG Xiao-hui;XU Xiao-na;QIN Xu-jun;WANG Feng(Department of Nutrition & Food Hygiene,School of Public Health,Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]第四军医大学军事预防医学系营养与食品卫生学教研室

出　　处：《生物学杂志》2019年第3期74-77,共4页Journal of Biology

基　　金：国家自然科学基金(81201928);陕西省自然科学基金(2016JM8048)

摘　　要：冷诱导RNA结合蛋白(Cirbp)是进化上保守的RNA结合蛋白,包含一个RNA识别结构域(RRM)和富含精氨酸-甘氨酸(RGG)结构域,在温度改变、低氧、辐射、药物、生长因子等作用下表达发生改变,从而对转录、转录后和翻译等进行调控。综述了Cirbp跨物种的进化保守性以及分子间的相互作用、细胞功能和在不同的生理和病理过程中的作用,包括昼夜节律、炎症、神经可塑性、干细胞的特性和癌症的发生发展等。Cold induced RNA binding protein (Cirbp) is an evolutionary conservative RNA binding protein, including a RNA domain (RRM) and a arginine - glycine (RGG) domain. The expression of Cirbp changes in temperature, hypoxia, radiation, drugs, growth factors and so on, so as to regulate transcriptional, post transcriptional, and translation. This article reviews the evolutionary conservatism and intermolecular interaction, cell function and role in different physiological and pathological processes, including circadian rhythm, inflammation, nerve plasticity, stem cell characteristics and cancer.

关 键 词：冷诱导RNA结合蛋白 温和低温 分子调控 生物学功能 

分 类 号：Q513[生物学—生物化学]