基于Cap蛋白研制的猪圆环病毒2型疫苗研究进展  

Progress on PCV-2 Vaccines Based on Cap Protein

作　　者：刘畅 陈艳 颜秋 吕其壮 LIU Chang;CHEN Yan;YAN Qiu;LV Qi-zhuang(College of Biology & Pharmacy,Yulin Normal University,Yulin,Guangxi,537000,China;Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology,Yulin,Guangxi,537000,China)

机构地区：[1]玉林师范学院生物与制药学院,广西玉林537000 [2]广西农产资源化学与生物技术重点实验,广西玉林537000

出　　处：《动物医学进展》2019年第6期83-87,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31860708);广西自然科学基金项目(2017GXNSFBA198025);广西高校中青年教师基础能力提升项目(2017KY0548)

摘　　要：猪圆环病毒相关疾病(PCVAD)是危害世界养猪业的主要疫病之一,主要由猪圆环病毒2型(PCV-2)引起。该病毒可引起感染猪免疫系统的破坏,造成严重的免疫抑制,继而引发多种病毒/细菌的混合感染与继发感染,给世界养猪业造成了巨大经济损失。近年来疫苗免疫接种是防控PCVAD的有效手段,由于衣壳蛋白(capside,Cap)是PCV-2的主要免疫保护性抗原,因此常被用作研制PCV-2基因工程疫苗的理想靶抗原。论文就PCV-2Cap蛋白基因工程疫苗的研究进展进行综述,以期为今后PCV-2新型疫苗的研究提供参考。Porcine circovirus type 2(PCV-2)is the causative agent of porcine circovirus-associated disease(PCVAD),which is one of the main diseases endangering swine herds worldwide.PCV-2 infection can result in the destruction of the immune system of infected pigs,causing severe immunosuppression,inducing co-infections or secondary infections with a number of viruses and(or)bacteria,and thereby producing a great economic loss to the world pig industry.Currently,vaccine immunization is an effective measure to prevent and control PCVAD.Due to the capside(Cap)is the major immune protective antigen of PCV-2,the Cap protein is usually regarded as the ideal target antigen that can be used for developing PCV-2 genetic engineering vaccine.The authors reviewed the current understanding of the gene engineering vaccine based on PCV-2 Cap protein in order to indicate the new direction of the study on PCV-2 vaccines and even provide reference for the effective prevention and control of PCVAD.

关 键 词：猪圆环病毒2型 疫苗 衣壳蛋白 免疫增强剂 

分 类 号：S858.28[农业科学—临床兽医学]