自噬对血管平滑肌细胞增殖的影响  

Effect of autophagy on proliferation of vascular smooth muscle cells

作　　者：魏海谅 秦旭平[1] WEI Hailiang;QIN Xuping(Laboratory of Vascular Biology,Institute of Pharmacy and Pharmacology,University of South China,Hengyang 421001,Hunan,China;Department of Pharmacology,Shaoyang University,Shaoyang 422000,Hunan,China)

机构地区：[1]南华大学药物药理研究所血管生物学实验室,湖南衡阳421001 [2]邵阳学院药理教研室,湖南邵阳422000

出　　处：《中南医学科学杂志》2019年第3期235-239,共5页Medical Science Journal of Central South China

基　　金：国家自然科学基金(81173060);南华大学归国人员基金资助项目(2010XQD44);湖南省教育厅科学研究项目(16C1446);邵阳市科技计划项目(2017FJ12)

摘　　要：血管平滑肌细胞异常增殖是血管增殖性疾病的病理基础,自噬是真核生物维持细胞内环境稳态的一种自我保护机制。近年来的研究发现,自噬参与多种细胞因子、血管活性物质、剪切应力、ncRNA等诱导的血管平滑肌细胞增殖,一些抗血管增生性疾病的药物往往通过调节自噬通量和自噬活性发挥抗血管平滑肌细胞增殖作用。本文综述了自噬对血管平滑肌细胞增殖的影响,为探索血管增生性疾病的病理生理机制提供新的思路。Abnormal proliferation of vascular smooth muscle cells is the pathological basis of vascular proliferative diseases.Autophagy is a self-protection mechanism of eukaryote to maintain the stability of intracellular environment.In recent years,the study found that autophagy participates in a variety of cytokines,vascular active substances,shear stress and ncRNA induced vascular smooth muscle cell proliferation,some drugs against vascular proliferative diseases often play the role of anti-proliferation of vascular smooth muscle cells by regulating autophagy flux and autophagy activity.This paper reviews the influence of autophagy on vascular smooth muscle cell proliferation and its mechanism,in order to provide new ideas for further understanding of the pathophysiology of vascular proliferative disease.

关 键 词：自噬 增殖 血管平滑肌细胞 血管增生性疾病 

分 类 号：R543.5[医药卫生—心血管疾病]