糖尿病性视网膜病变的循环生物标志物研究进展  

Progress in Circulating Biomarkers of Diabetic Retinopathy

作　　者：仰舒静 王珍[1] 杨卫华[2] 朱晓旋 王静娟 王烜 江佳莉 夏亥藤 YANG Shujing;WANG Zhen;YANG Weihua;ZHU Xiaoxuan;WANG Jingjuan;WANG Xuan;JIANG Jiali;XIA Haiteng(School of Nursing & Medicine,Huzhou University,Huzhou 313000,China;The First People's Hospital of Huzhou,Huzhou 313000,China)

机构地区：[1]湖州师范学院医学院·护理学院,浙江湖州313000 [2]湖州市第一人民医院,浙江湖州313000

出　　处：《湖州师范学院学报》2019年第4期68-74,共7页Journal of Huzhou University

基　　金：浙江省新苗人才计划项目(2017R427032)

摘　　要：基于相关的病理机制,目前已发现一些与DR可能相关的循环生物标志物,包括高级糖基化终末产物、基底膜和细胞外基质的生物标志物、与炎症和免疫有关的生物标志物、视黄醇结合蛋白质4)、同型半胱氨酸、免疫复合物及其抗体、遗传标志物等,其中,戊糖苷、Nε羧甲基赖氨酸和血清层粘连蛋白有助于DR的早期预测,C反应蛋白、白介素6、肿瘤坏死因子α和视黄醇结合蛋白质4有助于预测DR的进展及严重程度,但需要进一步设计严谨的实验性研究来证明这些标志物在DR的早期检测、监测进展以及预后方面的重要意义.Based on the relevant pathological mechanisms,some circulating biomarkers that may be associated with DR have been discovered,including advanced glycosylation end products,biomarkers of basement membrane and extracellular matrix,biomarkers related to inflammation and immunity,retinol binding protein 4,homocysteine,immune complexes and their antibodies,genetic markers,etc..Among them,pentose glycosides,Nεcarboxymethyl lysine and serum laminin contribute to the early prediction of DR,and C reactive protein,interleukin 6,tumor necrosis factorαand retinol binding protein 4 help to predict the progress and severity of DR.However,further rigorous experimental studies are needed to demonstrate the importance of these markers in the early detection,progression and prognosis of DR.

关 键 词：糖尿病视网膜病 高级糖基化终末产物 炎症和免疫 视黄醇结合蛋白质4 同型半胱氨酸 

分 类 号：R587.2[医药卫生—内分泌]