裸花紫珠片治疗慢性盆腔炎临床效果及对患者血清炎症因子的影响  

Callicarpa Nudiflora: Clinical Efficacy on chronic Pelvitis through Dampening of IL-1β,MCP-1 and GM-CSF

作　　者：陈燕荣 武明娟 王家俊[2] CHEN Yan-rong;WU Ming-juan;WANG Jia-jun(Gynecology Department of Wuxi Spaceflight Sanatorium,Wuxi,Jiangsu 214000)

机构地区：[1]江苏省无锡市航天无锡疗养院妇科,214081 [2]江苏省无锡市妇幼保健院妇产科

出　　处：《临床输血与检验》2019年第3期225-229,共5页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：江苏省卫计委妇幼保健重点项目(No.F201522)资助

摘　　要：目的探讨裸花紫珠片治疗慢性盆腔炎的临床效果及对患者血清白细胞介素-1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)和粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平的影响。方法以我院124例慢性盆腔炎患者为研究对象,其中给予头孢曲松钠、左奥硝唑氯化钠注射液静脉滴注治疗的62例为对照组;加用裸花紫珠片治疗的62例患者为观察组。通过主要症状的消失时间及中医证候积分变化评价其临床效果,监测用药前后血清IL-1β、MCP-1、GM-CSF水平。结果观察组患者的有效率(91.9%)明显高于对照组患者77.4%(P<0.05);经治疗后,观察组患者的体温降至正常、下腹痛消失、白带正常时间较对照组明显缩短(P<0.05);治疗后两组患者的主要中医症候积分、血清IL-1β、MCP-1、GMCSF水平显著低于治疗前,以观察组的下降更为明显(P<0.05)。结论裸花紫珠片利于促进慢性盆腔炎患者临床症状的消退,其机制可能在于调控血清IL-1β、MCP-1、GM-CSF水平而发挥抗炎作用,值得临床推广运用。Objective To investigate the clinical efficacy of Callicarpa nudiflora,a Traditional Chinese Medical(TCM)tablet,on alleviation of chronic pelvitis via reducing inflammatory cytokines of IL-1β,MCP-1 and GM-CSF.Methods One hundred and twenty four patients were randomly divided into control group(6 2 cases)and treatment group(62 cases).Patients in the control were intravenously given ceftriaxone sodium and metronidazole sodium chloride while those in the observation group were treated with the Chinese patient medicine tablets for four weeks in addition to the antibacterial agents.The disappear time of dominant clinical menifestations and their scoring were evaluated;IL-1β,MCP-1 and GM-CSF were measured.Results The efficiency of the TCM-combined treatments reached 91.9%,which was notably higher than that(7 7.4%,P<0.0 5)of the antibacterial agents administration in the control.The disappear time of temperature fell to normal,the pain in low abdominal and secretions of leukorrhea were significantly relieved with low syndrome scores in the patients with combined therapy when compared with those in the control(P<0.05).Additionally,the levels of IL-1β,MCP-1 and GM-CSF in the patients of observation group were decreased following combined treatments(P<0.0 5).Conclusion The combination of antibacterial agents with Callicarpa nudiflora tablets show a promising efficacy for treatment of chronic pelvic infections,and has ability to ameliorate inflammatory cytokines such as IL-1β,MCP-1 and GM-CSF.

关 键 词：慢性盆腔炎 裸花紫珠片 白细胞介素-1Β 单核细胞趋化蛋白-1 粒细胞-巨噬细胞集落刺激因子 

分 类 号：R711.33[医药卫生—妇产科学] R446.6[医药卫生—临床医学]