野三七皂苷类化学成分研究  

Saponins Chemical Constituents from the Roots of Panax vietnamensis var.fuscidiscus

作　　者：沈晓静 李晓波[2,3] 沈勇 杨生超[2,3] 姜薇薇 SHEN Xiao-jing;LI Xiao-bo;SHEN Yong;YANG Sheng-chao;JIANG Wei-wei(Yunnan Agricultural University,College of Science, Kumning 650201,China;The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunming 650201,China;Yunnan Agricultural University, National & Local Joint Engineering Research Center on Ormplasms Utilization & Innovation of Chinese Medicinal Materials in Southwest, Kunming 650201 , China)

机构地区：[1]云南农业大学理学院,云南昆明650201 [2]云南农业大学云南省药用植物生物学重点实验室,云南昆明650201 [3]云南农业大学西南中药材种质创新与利用国家地方联合工程研究中心,云南昆明650201

出　　处：《中药材》2018年第8期1894-1898,共5页Journal of Chinese Medicinal Materials

基　　金：云南省教育厅科学研究基金项目(2017ZZX037)

摘　　要：目的:研究野三七的皂苷类化学成分。方法:采用正相、反相硅胶柱层析、Sephadex LH-20、高效液相色谱等色谱方法对野三七乙醇提取物进行分离纯化,应用质谱和核磁共振等技术鉴定化合物结构。结果:从野三七70%乙醇提取物中分离鉴定了13个皂苷类化合物,分别为:20(S),24(S)-epoxydammarane-3β,6α,12β,25-tetrol(1)、majonoside R_2(2)、majonoside R_1(3)、vina-ginsenoside R_2(4)、vina-ginsenoside R_(11)(5)、ginsenoside Rg_1(6)、pseudo-ginsenoside RT_4(7)、20(R)-ginsenoside Rh_1(8)、notoginsenoside R_2(9)、ginsenoside Rf(10)、floralginsenoside A(11)、ginsenoside Rs_3(12)、vina-ginsenoside R_(14)(13)。结论:其中,化合物8、9、11、12为首次从该植物中分离得到。Objective:To investigate the chemical constituents of Panax vietnamensis var.fuscidiscus.Methods:The compounds were separated and purified by repeated column chromatography on silica gel,Sephadex LH-20,HPLC.Their structures were determined by spectroscopic data analyses of MS and NMR.Results:Thirteen compounds were obtained from 70% ethanol extract of Panax vietnamensis var.fuscidiscus and identified as 20(S),24(S)-epoxydammarane-3β,6α,12β,25-tetrol(1),majonoside R2(2),majonoside R1(3),vina-ginsenoside R2(4),vina-ginsenoside R11(5),ginsenoside Rg1(6),pseudo-ginsenoside RT4(7),20(R)-ginsenoside Rh1(8),notoginsenoside R2(9),ginsenoside Rf(10),floralginsenoside A(11),ginsenoside Rs3(12)and vina-ginsenoside R14(13).Conclusion:Compounds 8,9,11,12 are isolated from this plant for the first time.

关 键 词：野三七 皂苷类化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]